中国感染控制杂志2018，Vol.17Issue(2)：97-102,6.DOI:10.3969/j.issn.1671-9638.2018.02.002
一所综合医院连续三年医院感染发病率及病原菌耐药性监测报告
Incidence and antimicrobial resistance of pathogens of healthcare-associated infection in a general hospital for three consecutive years
摘要
Abstract
Objective To understand the occurrence of healthcare-associated infection (HAI),distribution of pathogens,and drug resistance in a general hospital in 2014-2016,provide basis for prevention and control of HAI.Methods Clinical data of hospitalized patients from January 2014 to December 2016 were collected by prospective and retrospective investigation,distribution and drug resistance of pathogens causing HAI were statistically analyzed.Results From 2014 to 2016,4 750 patients had 5 352 cases of HAI,incidence and case incidence of HAI were 2.19％ and 2.46％ respectively.Incidences of HAI in three years were 2.47％,2.07％,and 2.05％ respectively,showing a decreased tendency,difference was statistically significant (x2 =36.217,P＜0.01).Incidences of HAI were high in intensive care unit,department of neurosurgery,as well as department of burn and plastic surgery,the common HAI sites were respiratory tract,urinary tract,and surgical sites.The main pathogens causing HAI were gram-negative bacteria (76.10％).Resistance rates of Escherichia coli to cephalosporins and fluoroquinolones were relatively higher (＞60％);resistance rates of Klebsiella pneumoniae to carbapenems were relatively higher;resistance rates of Pseudomonas aeruginosa to carbapenems showed a increased tendency year by year (x2 =15.175,P =0.001);antimicrobial resistance rates of Acinetobacter baumannii were all＞50 ％.Methicillin-resistant Staphy lococcus aureus (SA) accounted for about 60％ of SA,methicillin-resistant coagulase negative Staphylococcus(CNS) accounted for more than 80％ of CNS,vancomycin-and linezolid-resistant Staphylococcus spp.were not found.Conclusion The common pathogens causing HAI in this hospital are higher.Scientific monitoring on HAI and regular analysis of clinical data are of great significance for guiding rational use of antimicrobial agents,controlling multidrug-resistant organisms,and reducing the occurrence of HAI.关键词
医院感染/病原菌/耐药性/抗药性,微生物/合理用药Key words
healthcare-associated infection/pathogen/drug resistance, microbial/rational drug use分类
医药卫生引用本文复制引用
邹秀珍,茆海丰,史家欣,田丽梅,刘善善,潘立业,陈亚男,刘菁..一所综合医院连续三年医院感染发病率及病原菌耐药性监测报告[J].中国感染控制杂志,2018,17(2):97-102,6.基金项目
国家自然科学基金项目(81300052) （81300052）
连云港市科技项目(SH1401) （SH1401）
