摘要
Abstract
OBJECTIVE: To probe into the efficacy of Calcium dobesilate capsule combined with compound Xueshuantong capsule in treatment of vitreous hemorrhage .METHODS:98 patients with vitreous hemorrhage admitted into Yidu the First People's Hospital from Mar.2015 to Apr.2016 were selected and divided into observation group and control group via random number table , with 49 cases in each .The control group was treated with Calcium dobesilate capsule , while the observation group was given Calcium dobesilate capsule combined with compound Xueshuantong capsule .Clinical efficacy , areas of hemorrhage spot , thicknesses of macular lutea , gray values of vision, volumes of hemangioma, level of serum vascular endothelial growth factor (VEGF), level of serum insulin-like growth factor 1 ( IGF-1 ) and incidences of adverse drug reactions of two groups were observed and compared . RESULTS:The total effective rate of observation group was 91.8％(45/49), which was significantly higher than that of the control group (77.6％, 38/49), with statistically significant difference (P<0.05);after treatment, the areas of hemorrhage spot , thicknesses of macular lutea , gray values of vision and volumes of hemangioma of both groups had been significantly improved , and those of the observation group were significantly better than the control group , with statistically significant differences ( P<0.05 ); after treatment , levels of serum VEGF and IGF-1 of both groups had been significantly decreased , and those of the observation group were significantly lower than the control group , with statistically significant differences ( P<0.05);the incidence of adverse drug reactions of observation group was 8.0％(4/49), which was significantly lower than that of the control group (30.6％, 15/49), with statistically significant difference ( P <0.05 ).CONCLUSIONS: The efficacy of Calcium dobesilate capsule combined with compound Xueshuantong capsule in treatment of vitreous hemorrhage is remarkable , which can significantly improve clinical syndromes, promote vision, reduce levels of serum VEGF and IGF-1, with low incidence of adverse drug reactions .关键词
羟苯磺酸钙/复方血栓通胶囊/玻璃体积血/糖尿病性视网膜病变/疗效Key words
Calcium dobesilate/Compound Xueshuantong capsule/Vitreous hemorrhage/Diabetic retinopathy/Efficacy分类
医药卫生
