中国医院用药评价与分析2018，Vol.18Issue(2)：251-254,4.DOI:10.14009/j.issn.1672-2124.2018.02.034
2012—2016年南京医科大学附属常州市妇幼保健院抗菌药物使用量与葡萄球菌耐药率的相关性分析
Analysis on Correlation between the Dosage of Antibiotics and Drug Resistance Rate of Staphylococcus in Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University During 2012-2016
摘要
Abstract
OBJECTIVE:To investigate the correlation between the dosage of antibiotics and drug resistance rate of staphylococcus in Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University ( hereinafter referred to as "our hospital") during 2012-2016 , so as to provide references for clinical rational medication .METHODS:The defined daily dose system ( DDDs ) , detection of staphylococcus and drug resistances rates of staphylococcus to general antibiotics in different hospital wards during 2012-2016 were analyzed , to discuss the correlation between the dosage of antibiotics and changes of drug resistance rate of staphylococcus ( staphylococcus aureus, staphylococcus epidermidis ).RESULTS: In 2012, the DDDs of various antibiotics in our hospital was relatively high , which presented decreasing trend in 2013 and part of them showed ups and downs after then .During 2012-2016, the DDDs of cephalosporins had kept the first place in all antibiotics all the time;in 2012, the DDDs of the second and third generation of cephalosporins took higher proportion in the DDDs of cephalosporins than that of the first generation , during 2013-2016 , the DDDs of the first generation of cephalosporins accounted for 50％, while the second and third generation of cephalosporins took less proportions .Staphylococcus in our hospital mainly including staphylococcus aureus and staphylococcus epidermidis , during 2012-2016, staphylococcus was 100％ sensitive to linezolid and vancomycin , and was sensitive to other antibiotics in different degrees .Results of Pearson correlation analysis indicated that the drug resistance rates of staphylococcus aureus and staphylococcus epidermidis were more likely to be influenced by the dosages of antibiotics of penicillins , cephalosporins, aminoglycosides, tetracyclines, fluoroquinolones and macrolides . CONCLUSIONS: There is indeed a certain correlation between the dosage of antibiotics and drug resistance rate of staphylococcus , along with the progress of specialized renovation , the dosage and selection of antibiotics in our hospital will be more rational .关键词
抗菌药物/葡萄球菌/耐药率/相关性Key words
Antibiotics/Staphylococcus/Resistance Rate/Correlation分类
医药卫生引用本文复制引用
陶文婷,沈建峰,张克良,奚彩萍..2012—2016年南京医科大学附属常州市妇幼保健院抗菌药物使用量与葡萄球菌耐药率的相关性分析[J].中国医院用药评价与分析,2018,18(2):251-254,4.基金项目
常州市妇幼保健院院级课题(No.YJ2016019) （No.YJ2016019）
