安徽中医药大学学报2017，Vol.36Issue(6)：76-79,4.DOI:10.3969/j.issn.2095-7246.2017.06.021
单剂量复方苦参注射液对吉西他滨在大鼠体内药物代谢动力学参数的影响
Influence of Single-dose Compound Kushen Injection on Pharmacokinetic Parameters of Gemcitabine in Rats
摘要
Abstract
Objective To investigate the influence of combined administration of single-dose Compound Kushen Injection (CKI) and gemcitabine hydrochloride for injection on the pharmacokinetic parameters of gemcitabine in rats.Methods A total of 24 healthy Sprague-Dawley (SD) rats (12 male and 12 female rats) were randomly divided into control group and high-,middle-,and low-dose CKI groups.Blood samples were collected at the orbit at 13 time points,and high-performance liquid chromatography was used to measure the concentration of gemcitabine in blood samples.DAS 3.0 software was used to calculate pharmacokinetic parameters.Results The pharmacokinetic process of intravenously injected gemcitabine in SD rats was fitted to the two-compartment model.There were no significant differences between single and combined administration in distribution half-life time (t1/2α),elimination half-life time (t1/2β),clearance,and area under the plasma concentration-time curve (AUC).Conclusion Single-dose CKI has no significant effect on the pharmacokinetie parameters of gemcitabine in rats,suggesting that single-dose CKI can be combined with gemcitabine hydrochloride for injection in clinical practice.关键词
盐酸吉西他滨/复方苦参注射液/药物代谢动力学参数Key words
Gemcitabine hydrochloride/Compound Kushen Injection/Pharmacokinetic parameter分类
医药卫生引用本文复制引用
孟子路,张盛,陈卫东,彭慧..单剂量复方苦参注射液对吉西他滨在大鼠体内药物代谢动力学参数的影响[J].安徽中医药大学学报,2017,36(6):76-79,4.基金项目
安徽省科技专项资金项目(13Z04013) （13Z04013）
安徽省科技厅公益联动项目(1501Id04004) （1501Id04004）
安徽道地中药材品质提升协同创新中心项目(皖教科[2013]2号) （皖教科[2013]2号）
