吉林大学学报（医学版）2018，Vol.44Issue(1)：30-35,6.DOI:10.13481/j.1671-587x.20180106
粗毛纤孔菌对寒凝血瘀证大鼠血液流变学的影响及谱效关系分析
Influence of Inonotus hispidus in hemorheology in rat model with blood stasis due to cold syndrome and analysis on spectral efficiency
摘要
Abstract
Objective:To explore the effects of the activating circulation to remove blood stasis through observingthe influence of Inonotus hispidus on hemorheology in the rat models with blood stasis due to cold syndrome..Methods:The rats were randomly divided into normal control group,blood stasis model group,positive control group,low and high doses ofInonotus hispidus (S1-S6) sample groups;there were 15 groups,and 12 rats were in each group.Except for normal control group,the rats in other groups were injected adrenaline hydrochloride and immersing in ice water to build the blood stasis due to cold syndrome rat models.The indexes of hemorheoloy of the rats were detected,and the HPLC spectrum-effect relationship was analyzed.Results:The yellow fruiting bodies (S3-S6) of Inonotus hispidus which were parasitic on the different trees significantly improved the hemorheological indexes in the rat models.Compared with model group,the blood viscosity and whole blood viscosity of the rats in high dose of yellow fruiting body of Inonotus hispidus group were decreased (P＜0.05).The black fruiting body of Inonotus hispidus showed the similar effect to the yellow fruiting body,but the hemorheological indexes of the rats in black fruiting body of Inonotus hispidus group had no significant changes compared with model group (P ＞ 0.05).The results of the spectrum-effect showed that the corresponding components of 11 chromatographic peaks were closely correlated with the changes of plasma viscosity,and the correlation coefficient ＞ 0.8.Through identification,four compounds of them were named phellibaumin A,phelligridin C (cis),phelligridin C (trans),phelligridin D and 3'4'-dihydroxy-5-[(11-hydroxyphenyl)-6,7-vinyl]-3,5-dioxa-fluoren-5-one.Conclusion:The yellow fruiting bodies of Inonotus hispidus which are parasitic on the different trees can decrease the blood viscosity and whole blood viscosity and have the effects of activating the circulation to remove blood stasis.关键词
粗毛纤孔菌/寒凝血瘀证/血液流变学/谱效分析Key words
Inonotus hispidus/blood stasis due to cold syndrome/hemorheology/spectrum-effect relationship分类
医药卫生引用本文复制引用
李庆杰,包海鹰,图力古尔,李玉..粗毛纤孔菌对寒凝血瘀证大鼠血液流变学的影响及谱效关系分析[J].吉林大学学报（医学版）,2018,44(1):30-35,6.基金项目
国家自然科学基金资助课题(31270088) （31270088）
教育部长江学者和创新团队发展计划项目资助课题(IRT-15R25) （IRT-15R25）
