吉林大学学报（医学版）2018，Vol.44Issue(1)：142-146,5.DOI:10.13481/j.1671-587x.20180127
染色体9p21遗传变异与中国汉族人群冠心病的关联性
Association between genetic variations in 9p21 region and coronary heart disease in Chinese Han population
摘要
Abstract
Objective:To analyze the association of the genetic variations of rs2383206 and rs2383207 in 9p21region with the coronary heart disease (CHD) in the Chinese Han population,and to explore whether chromosome 9p21 is a susceptibility region for CHD.Methods:Case-control study was conducted.A total of 580 CHD patients were selected as case group,and 539 cases of non-cardiovascular disease patients or normal people with matched age and sex were selected as control group.The rs2383206 and rs2383207 loci of the subjects were genotyped with Sequenom MassARRAY time of flight mass spectrometer (TOF).Results:The smoking,waist-to-hip ratio (WHR),hypertension,diabetes mellitus,systolic blood pressure (SBP),diastolic blood pressure (DBP) and total cholesterol (TC) of the subjects in two groups were statistically different (P＜0.05).Compared with control group,the ratios of patients with smoking,hypertension and diabetes mellitus of the patients in case group were increased (P＜0.05);the WHR,SBP,DBP and TC level were also increased (P＜0.05).There was no significant difference in the genotypic distribution of rs2383206 between case group and control group (x2 =4.623,P＞0.05),while the genotypic distribution of rs2383207 was statistically different (x2 =8.936,P＜0.05);the distribution frequency of AA genotype in case group (8.3％) was significantly lower than that in control group (13.6％) (P＜0.05).Conclusion:Smoking,WHR,hypertension,diabetes mellitus,SBP,DBP and TC may be the risk factors for CHD;the AA genotype of 9p21 rs2383207 loci may be the protective genotype of CHD.关键词
染色体9p21/冠心病/遗传变异/病例-对照研究Key words
chromosome 9p21/coronary heart disease/variation/case-control study分类
医药卫生引用本文复制引用
郑东春,张天融,刘洪泊,陈怀基,王琪,许峰,张月竹,周丽婷,叶琳..染色体9p21遗传变异与中国汉族人群冠心病的关联性[J].吉林大学学报（医学版）,2018,44(1):142-146,5.基金项目
教育部博士点专项基金资助课题(20100061110071) （20100061110071）
