重庆医学2018，Vol.47Issue(7)：871-874,4.DOI:10.3969/j.issn.1671-8348.2018.07.003
HERV-HLTR相关蛋白2在肝癌中的表达及其临床意义
Expression and clinical significance of HERV-HLTR-associating protein 2 in hepatocellular carcinoma
摘要
Abstract
Objective To investigate the expression of HERV-HLTR-associating protein 2(HHLA2).in hepatocellular carcinoma(HCC) tissue and its relationship with different pathological grades,clinical stages,liver function and serum AFP level.Methods The positive rate of HHLA2 expression in 150 cases of paraffin-embedded HCC tissues was detected by immunohistochemistry.Ten cases of normal liver tissue specimens from health donors served as the normal control.The differences of HHLA2 expression in HCC tissues were compared among different pathological grades,clinical stage,liver function grades and serum AFP levels.Results The positive expression rate of HHLA2 in HCC tissue was significantly higher than that in normal control (P＜0.05).The positive rate of HHLA2 expression in low differentiated HCC tissue was highest.The positive rate of HHLA2 expression in the low differentiation and moderate differentiation HCC groups was significantly higher than that in the high differentiation group (P＜0.05).The positive expression rate in the patients with Barcelona stage C and D was significantly higher than that in the patients with the stage A and B(P＜0.05).The positive expression rate in the patients with Child-Pugh stage A was significantly higher than that in the patients with stage B and C(P＜0.01).While the HHLA2 expression rate had no statistically significant difference among different ages and different serum AFP levels(P＞0.05).Conclusion The positive expression rate of HHLA2 in cancer tissues of HCC patients is significantly increased.HHLA2 might play a certain role in the occurrence,development and metastasis of HCC.关键词
癌,肝细胞/淋巴细胞/HERV-HLTR相关蛋白2/免疫适逸Key words
carcinoma, hepatocellular/lymphocytes/HHLA2/immune escape分类
医药卫生引用本文复制引用
李国,张晓峰,太云翔,代亚海,汤旭东,陈琨..HERV-HLTR相关蛋白2在肝癌中的表达及其临床意义[J].重庆医学,2018,47(7):871-874,4.基金项目
国家自然科学基金面上项目资助(81372470). （81372470）
