摘要
Abstract
Objective To investigate the effect of different dosages of dexmedetomidin on assisted general anesthesia before anesthesia induction in radical resection of rectal cancer.Methods 92 patients with rectal cancer receiving radical resection of rectal cancer in our hospital were randomly assigned to treatment group (10 min before induction of anesthesia,auxiliary use of low dose dexmedetomidine,0.5 μg/kg) and control group (10min before induction of anesthesia,auxiliary use of high dose dexmedetomidin,1.0 μg/kg).Both groups received tracheal intubation vein combined with general anesthesia.Heart rate (HR) and mean arterial pressure (MAP) at admission,after dexmedetomidine,after intubation,at 5min,during laparotomy,during abdominal closure,and during extubation were compared between the two groups.Anesthetic effects and inflammatory factor levels [interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α)] were recorded.The incidence of adverse reactions during anesthesia period was compared.Results There was no between-group significant difference in anesthesia induction time,anesthesia maintenance time,anesthesia recovery time and endotracheal catheter extraction time (P ＞ 0.05).In both groups,HR was lower and MAP higher after dexmedetomidin than admission (P ＜ 0.05) and these indices at other time points were similar to admission (P ＞ 0.05).There was no significant difference in HR and MAP at each time point between the two groups (P ＞ 0.05).1 d after operation,IL-6 and TNF-α were higher than those that 1 d preoperative (P ＜ 0.05),but there was no significant difference between the two groups (P ＞ 0.05).The incidence of adverse reaction in the treatment group was lower than that in the control group (P ＜ 0.05).Conclusion Effect of low dose (0.5 g/kg) and high dose (1 g/kg) dextromethorphal 10min before induction of anesthesia is similar for rectal cancer radical surgery.They both help to stabilize hemodynamics and alleviate inflammation.But the lower dosage has low incidence of adverse reactions during anesthesia,indicating better safety profile.关键词
不同剂量/右美托咪定/全麻/直肠癌根治术Key words
different dosages/dexmedetomidine/general anesthesia/radical resection of rectal cancer分类
医药卫生
