摘要
Abstract
Objective:To systemically review the effectiveness and safety of Qingkailing injection in the treatment of pediatric pneumonia.Methods:The databases of Web of science,Embase,Cochrane Libray,Pubmed,CNKI,Wan Fang,VIP and CBM were retrieved for collecting the randomized controlled trials (RCT) about the treatment of pediatric pneumonia with Qingkailing injection.The selection and data collection were conducted independently by two investigators,and the included studies were assessed.All the Meta-analyses were performed by Review Manager 5.3.3.Results:Twenty-two RCTs and 2,400 cases were included.From the results of Meta-analysis,the effectiveness of Qingkailing group was superior to the control group in the overall efficiency,defervescence time,cough disappeared time,rales disappeared time,breathing rate improvement time,vomiting improvement time (P＜0.05),but the length of hospital stay was not reduced by the addition of Qingkailing injection (P＞0.05).Conclusion:The existing literature supports the treatment of pediatric pneumonia by Qingkailing injection.However,due to the low quality of supporting documents,more high quality,large samples and multi-center RCTs are still needed to be verified.关键词
清开灵注射液/小儿/肺炎/随机对照试验/Meta分析Key words
Qingkailing injection/pediatric/pneumonia/randomized controlled trial/Meta-analysis分类
医药卫生
