儿科药学杂志2018，Vol.24Issue(3)：25-29,5.DOI:10.13407/j.cnki.jpp.1672-108X.2018.03.008
雾化吸入布地奈德和肺表面活性物质预防支气管肺发育不良的临床研究
Aerosol Inhalation of Budesonide and Pulmonary Surfactant to Prevent Bronchopulmonary Dysplasia
摘要
Abstract
Objective:To investigate the effect of the aerosol inhalation of budesonide combined with pulmonary surfactant (PS) basis on the mechanical ventilation in treatment of bronchopulmonary dysplasia (BPD) and observe the drug adverse reactions.Methods:One hundred and twenty preterm infants were involved in this study,and were randomly divided into 3 groups.The treated group was given a mixture of budesonide suspension (0.25 mg/kg) and PS (100 mg/kg) aerosol inhalation combined with mechanical ventilation.The control group 1 received PS (100 mg/kg) intratracheal instillation combined with mechanical ventilation.The control group 2 received PS (100 mg/kg) aerosol inhalation combined with mechanical ventilation.Mean airway pressure (MAP),oxygenation index (OI),pH,arterial oxygen tension (PaO2),arterial carbon dioxide tension (PaCO2),the contents of macrophage migration inhibitory factor (MIF) and phospholipid transfer protein (PLTP) in bronchoalveolar lavage fluid (BALF) were detected.The time of extubated,duration of supplemental oxygen,duration of hospitalization,the incidence of hyperglycemia,patent ductus arteriosus (PDA),intraventricular hemorrhage (IVH),retinopathy of prematurity (ROP) and the BPD occoured and death cases were compared.Results:There were no significant differences between the three groups of Pa02,PaC02,and pH (P＞0.05).There were significant differences between the three groups of MAP,OI,MIF and PLTP (P＜0.01).The content of MIF in the treated group was significantly lower than the two control groups at each time point,while the content of PLTP was higher (P＜0.01).The incidence of BPD,the time of extubation,duration of supplemental oxygen and hospitalization in treated group were significantly lower in the treated group than control groups (P＜0.05).The motality,the incidence of hyperglycemia,PDA,IVH and ROP in these three groups were no significant differences (P＞0.05).Conclusion:Combined aerosol inhalation of budesonide suspension and PS can reduce the incidence of BPD in preterm infants in early stage,and there are no drug adverse reactions detected.关键词
布地奈德混悬液/肺表面活性物质/氧驱雾化/早产儿/支气管肺发育不良/机械通气Key words
budesonide suspension/pulmonary surfactant/oxygen-driven aerosol inhalation/preterm infant/bronchopulmonary dysplasia/mechanical ventilation分类
医药卫生引用本文复制引用
曹洋洋,姚国,王燕,史宝海,刘俊丽,李桂芳..雾化吸入布地奈德和肺表面活性物质预防支气管肺发育不良的临床研究[J].儿科药学杂志,2018,24(3):25-29,5.基金项目
泰安市科技进步奖,编号JB2016-2-19-4. （）
