摘要
Abstract
Objective:To compare the therapeutic efficacy of atomization inhalation of 3％ hypertonic saline and recombinant human interferon (rhIFN) α-2b in the treatment of children with mild to moderate bronchiolitis.Methods:A total of 134 children with mild to moderate bronchiolitis hospitalized in department of pediatrics of Anqing Hospital Affiliated to Anhui Medical University from November 2015 to April 2017 were randomly divided into three groups:children in the control group received atomization inhalation (salbutamol solution 0.5 mg+budsonide 0.5 mg) twice a day.Children in hypertonic saline group received additional atomization inhalation of 3％ hypertonic saline 4 mL,3 times a day every 4 hours based on the treatment of the control group.Children in interferon group received additional atomization inhalation of rhIFN α-2b (200,000 IU/kg each time) twice a day based on the treatment of the control group.The clinical severity scores before and after treatment in 5 days,adverse reactions,number of withdrew from the study in each group and the length of stay were recorded.Results:Among the 134 cases,3 cases in the control group,2 cases in hypertonic saline group and 2 cases in interferon group withdrew from the study because of treatment with additional drugs due to aggravation of the disease (P＞0.05).Four cases in hypertonic saline group withdrew because of paroxysmal irritable cough,while no obvious adverse reactions were observed in interferon group or control group (P＜0.05).Practically,123 cases were enrolled in the clinical study,among which 40 cases in control group,42 cases in hypertonic saline group and 41 cases in interferon group.The severity scores of hypertonic saline group were lower than that of interferon group from the 2nd to 4th day after treatment,and the differences were statistically significant (P＜0.01).The severity scores of hypertonic saline group were lower than those of the control group from the 2nd to 5th day after treatment,and the differences were statistically significant (P＜0.01).The severity scores of interferon group were lower than those of the control group on the 4th and 5th day after treatment and the differences were statistically significant (P＜0.01).The hospital stays of both hypertonic saline group and interferon group were shorter than that of the control group and the differences were statistically significant (P＜0.05).Conclusion:Atomization inhalation of 3％ hypertonic saline and rhIFN α-2b can improve the condition of children with mild to moderate bronchiolitis.Both of them can shorten hospital stay,but the atomization inhalation of 3％ hypertonic saline may cause irritable cough.关键词
毛细支气管炎/高渗盐水/重组人干扰素α-2b/雾化吸入Key words
bronchiolitis/hypertonic saline/recombinant human interferon α-2b/atomization inhalation分类
医药卫生
