分析测试学报2017，Vol.36Issue(12)：1439-1444,6.DOI:10.3969/j.issn.1004-4957.2017.12.004
手性金属-有机骨架[Cu3(HL)2(L)2(bpy)3]·4H2O用于高效液相色谱拆分手性化合物
Separation of Chiral Compounds Using a Chiral Metal-Organic Framework [Cu3(HL)2(L)2(bpy)3] · 4H2O for High Performance Liquid Chromatography
摘要
Abstract
Chiral metal-organic frameworks (MOFs),as a novel type of porous material with many properties such as large surface area,diverse structure,adjustable pore size and good chemical stability,have aroused much attention in the field of chromatographic separation.In this paper,a homochiral MOF [Cu3 (HL)2(L)2(bpy)3] · 4H2O with 2D chiral network was synthesized through the reaction of two kinds of ligands((1R,2R)-1,2-cyclohexanedicarboxylic acid(H2L) and 4,4'-bipyridine(bpy)) with copper ion via a solvothermal approach.The homochiral MOF [Cu3 (HL)2(L)2 (bpy)3] · 4H2O was used as chiral stationary phase to fabricate a packed column for high-performance liquid chromatography.To investigate the MOF's chiral recognition ability,a series of racemates were separated on the homochiral MOF column under normal phase condition using n-hexane-isopropanol as mobile phase.The homochiral MOF column exhibited a good resolving ability towards 10 kinds of chiral compounds,including alcohols,ketones,acids,epoxy compounds and ethers,etc.The reproducibility and stability of the homochiral MOF column were evaluated.The effect of the injected mass of chiral compound on separation was also investigated.Results indicated that the homochiral MOF column has a good reproducibility and stability for enantioseparation.关键词
金属-有机骨架/高效液相色谱/手性固定相/手性分离Key words
metal-organic framework/high-performance liquid chromatography/chiral stationary phase/chiral separation分类
化学化工引用本文复制引用
李丽,付仕国,袁宝燕,谢生明,袁黎明..手性金属-有机骨架[Cu3(HL)2(L)2(bpy)3]·4H2O用于高效液相色谱拆分手性化合物[J].分析测试学报,2017,36(12):1439-1444,6.基金项目
国家自然科学基金资助项目(21365024,21675141) （21365024,21675141）
