国际医药卫生导报2018，Vol.24Issue(1)：15-17,3.DOI:10.3760/cma.j.issn.1007-1245.2018.01.004
孕妇血清PAPPA水平与妊娠并发症的相关性研究
Study on the correlation between serum PAPPA level of pregnant women and pregnancy complications
摘要
Abstract
Objective To study the correlation between serum pregnancy associated plasma protein A (PAPPA) level of pregnant women and pregnancy complications. Methods From Sep. 2010 to Dec. 2016, 4920 Down syndrome screening cases in our hospital were selected as observation group, and during the same period 2350 normal pregnant women were selected as control group. All the pregnant women were followed up and their data were collected and analyzed, and the serum PAPPA levels in the two groups were compared. Results 3400 cases in the observation group were successfully followed up, including 2145 cases with normal pregnancy and prognosis (63.09％), 71 cases with spontaneous abortion or termination of pregnancy (2.09％), 65 cases with threatened abortion (1.91％), 48 cases with pregnancy induced hypertension syndrome (1.41％), 99 cases with gestational diabetes (2.91％), and 156 cases with gestational impaired glucose tolerance (4.59％). 1700 cases in the control group were successfully followed up. The statistical analysis showed that the serum PAPPA level in the observation group was significantly lower than that in the control group at different gestational weeks (P<0.05). The lower the serum PAPPA level was, the higher the incidences of spontaneous abortion or termination of pregnancy, threatened abortion, pregnancy induced hypertension syndrome, gestational diabetes, and gestational impaired glucose tolerance were. Conclusion The low serum PAPPA level of pregnant women can promote the occurrence of pregnancy complications, such as spontaneous abortion, threatened abortion, pregnancy induced hypertension syndrome, and gestational diabetes.关键词
孕妇/血清PAPPA/妊娠并发症Key words
Pregnant women/Serum PAPPA/Pregnancy complications引用本文复制引用
袁路,张富青,刘敏,邹芳,僧雪雁..孕妇血清PAPPA水平与妊娠并发症的相关性研究[J].国际医药卫生导报,2018,24(1):15-17,3.基金项目
郑州市 2013 年度科技发展计划(20130483) Scientific and Technological Development Plan of Zhengzhou City in 2013 (20130483) （20130483）
