河北医学2018，Vol.24Issue(2)：211-215,5.DOI:10.3969/j.issn.1006-6233.2018.02.008
阿司匹林治疗原发性高血压合并冠心病的有效性及其对血浆黏度及血小板聚集率的影响
The Efficacy of Aspirin in the Treatment of Primary Hypertension with CHD and its Effect on Plasma Viscosity and Platelet Aggregation Rate
摘要
Abstract
Objective: To observe the curative efficiency of aspirin on primary hypertension combined with coronary heart disease(CHD) and its influence on plasma viscosity and platelet aggregation rate. Meth-ods:A total of 107 cases of primary hypertension patients with coronary heart disease were randomly divided into two groups by the random number table method: the study group (56 cases) and the control group (51 cases). The control group were given Telmisartan (40mg/d), Isosorbide Dinitrate tablets (30mg once, 3 times per day),while the study group were given aspirin(100mg/d) on the basis of the control group. Com-pare the blood pressure, blood lipid levels, left ventricular ejection fraction (LVEF), plasma viscosity and platelet aggregation rate changes of the two groups before and after 6 months' treatment. Results: After 6 months'treatment,the level of blood pressure,TC,TG,plasma viscosity and platelet aggregation rate of both groups were all declined on different degree,while the level of plasma viscosity and platelet aggregation rate of the study group were more significant lower than that of the control group(P<0.05). In addition,the LVEF of both groups were all increased significantly (P<0.01), and the LVEF level of the study group were signifi-cantly higher than the control group (P<0.05); the total effective rate of the study group were significantly higher than the control group (90.9% vs 76.5%,P<0.05). Conclusion:The therapy of aspirin can improve the blood viscosity and LVEF level for primary hypertension patients with CHD,and improve the curative effi-ciency as well.关键词
替米沙坦片/阿司匹林/原发性高血压/冠心病Key words
Telmisartan tablets/Aspirin/Primary hypertension/Coronary heart disease引用本文复制引用
崔琳琳,高国杰,胡桃红..阿司匹林治疗原发性高血压合并冠心病的有效性及其对血浆黏度及血小板聚集率的影响[J].河北医学,2018,24(2):211-215,5.基金项目
国家科技计划课题,(编号:2009BAI86B04) （编号:2009BAI86B04）
