摘要
Abstract
Objective:To investigate the effect of different antiplatelet regimens on vascular endothelial function and inflammatory factors after drug-eluting stent implantation. Methods:300 patients with coronary heart disease and came to our hospital for drug eluting stent implantation from January 2015 to December 2016 were enrolled and randomly divided into monotherapy group and dual antiplatelet therapy group. Monotherapy group receive clopidogrel antiplatelet treatment whereas dual antiplatelet therapy group receive clopidogrel plus aspirin in the treatment. The vascular endothelial function indexes such as ET-1,NO and inflammatory factors such as TNF-a,IL-1,CRP were compared between the two groups at the time before operation,12 hours af-ter operation and 30 days after operation. Results:After operation,the levels of ET-1,TNF-a and CRP in-creased significantly,and NO decreased significantly.After 30 days antiplatelet treatment,the levels of ET-1, TNF-a and CRP decreased, and NO increased. Besides, ET-1 and CRP levels in dual antiplatelet therapy group were less than monotherapy group at 30 days after operation and they change more in dual antiplatelet therapy group. Level of TNF-a showed no significant difference between the two group, however, dual anti-platelet therapy group showed greater reductions than monotherapy group (P<0.05). Conclusion: Compared with clopidogrel monotherapy, clopidogrel plus aspirin can improve the vascular endothelial function and re-duce the inflammatory reaction in patients after drug-eluting stent implantation.关键词
氯吡格雷/阿司匹林/双联/药物洗脱支架/内皮功能/炎症因子Key words
Clopidogrel/Aspirin/Dual antiplatelet/Drug-eluting stent/Endothelial func-tion/Inflammatory factors
