河北医学2018，Vol.24Issue(2)：321-325,5.DOI:10.3969/j.issn.1006-6233.2018.02.038
雷贝拉唑治疗老年慢性萎缩性胃炎的疗效及对血清胃泌素和内皮素水平的影响
Efficacy of Ray Bella in the Treatment of Chronic Atrophic Gastritis in Elderly Patients and its Effect on Serum Levels of Gastrin and Endothelin
摘要
Abstract
Objective:To study the effect of Ray Bella in the treatment of senile chronic atrophic gastri-tis and its influence on the serum levels of Gastrin and Endothelin. Methods: 100 cases of elderly patients with chronic atrophic gastritis admitted in our hospital from July 2014 to July 2015 were selected and randomly divided into observe group and control group(50 cases in each group). Patients in the control group were giv-en omeprazole (20mg/time,2time/day),levofloxacin (0.2 g/time,2 time/day), and furazolidone (100mg/time,3time/day). Patients in the observation group were given rabeprazole azole (20mg/time,1time/day), levofloxacin(0.2g/time,2 time/day),furazolidone(100mg/time,3 time/day). The treatments for patients in both groups were last two weeks. After treatment,the serum levels of gastrin and endothelin,the adverse reac-tions and the efficacy between treatments were compared.Result After treatment,the GAS and ET levels in pa-tients of the observation group were(176.38 ± 13.29)ng/L, which higher than that in patients of the control group(142.27±12.32)ng/L;While,serum ET level(62.82±5.72)ng/L were lower than that in patients of the control group(78.39±6.59)ng/L. The differences of the two items were all statistically significant(P<0.05). The incidence rates of adverse reactions in observation group was 10.00%(5/50 cases),which less than that in the control group 38.00%(19/50 cases). The difference was statistically significant(P<0.05). The total ef-fective rate of the observation group was 94.00%(47/50 cases), which higher than that in the control group 76.00%(38/50). The difference was statistically significant(P<0.05);Conclusion:Ray Bella has a signifi-cant effect in the treatment of chronic atrophic gastritis in elderly patients, which could significantly improve the level of serum gastrin,reduce the level of endothelin,and reduce the incidence of complications.关键词
雷贝拉唑/老年慢性萎缩性胃炎/血清胃泌素/内皮素Key words
Ray bella/Senile chronic atrophic gastritis/Gastrin/Endothelin引用本文复制引用
朴仁女,赵冬..雷贝拉唑治疗老年慢性萎缩性胃炎的疗效及对血清胃泌素和内皮素水平的影响[J].河北医学,2018,24(2):321-325,5.基金项目
辽宁省自然科学基金资助项目,(编号:20052070) （编号:20052070）
