摘要
Abstract
Used the doxorubicin(DOX)as small molecule drug model,the DOX-loaded poly-L-lactide (PLLA)porous microspheres(PMs)were designed by adsorption method. The particle size distribution,aerodynamic properties,surface morphology,physical and chemical properties of PLLA PMs,and its successive drug-loaded conjugates,were detremined by various characterization techniques such as field emission-scanning electron microscope(FE-SEM),Fourier transform infrared spectrophotometry(FTIR),X-ray powder diffraction(XRPD)and differential scanning calorimetry (DSC),among others. Further,the drug loading,as well as encapsulation efficiencies and DOX-release performance in vitro,were also investigated. The PLLA PMs resulted in decreased encapsulation efficiencies(56%,51%,and 44%)with the increase in drug loading efficiencies(2.9%, 4.0% and 4.6%). DOX-loaded PLLA PMs exhibited sustained-release profiles,in which the effect lasted more than 5 days. These porous microspheres can be used as an efficient platform due to their excellent aerodynamic properties and sustained release effect,which will potentially play a significant role in pulmonary drug delivery.关键词
阿霉素/多孔微球/聚乳酸/体外释放/肺部给药Key words
doxorubicin/porous microspheres/poly-L-lactide/in vitro release/pulmonary drug delivery分类
医药卫生
