华西口腔医学杂志2018，Vol.36Issue(1)：4-8,5.DOI:10.7518/hxkq.2018.01.002
新疆维吾尔族和汉族儿童龋病与人类白细胞抗原-DQB1等位基因多态性的相关性研究
Association between the dental caries and the human leucocyte antigen DQB1 allele polymorphisms among the Uygur and Han children in Xinjiang
摘要
Abstract
Objective This study aims to investigate the association between human leucocyte antigen (HLA)-DQB1 allele polymorphisms and the presence dental caries among the Uygur and Han children in Xinjiang.Methods HLA-DQB 1 allele in the Uygur and Han children with dental caries and healthy control in Xinjiang was tested (n=40) using the polymerase chain reaction-sequence specific primer (PCR-SSP) DNA parting technology.Results A total of five specific loci were detected in the HLA-DQB 1 locus among the Uygur and Han children.The frequency of the HLA-DQB1*02 allele in the Han group with severe caries (12.5％) was significantly lower than in the control group (32.5％) (P＜0.05,OR=0.297).Moreover,the frequency of the HLA-DQB1*05 allele in the Uygur group with severe caries (37.5％) was significantly higher than in the control group (17.5％) (P＜0.05,OR=2.829).Conclusion Caries susceptibility among the Uygur and Han children in Xinjiang is related to the HLA-DQB 1 allele.The HLA-DQB 1*02 allele may protect against caries among the Han children,whereas the HLA-DQB 1*05 allele may be responsible for the susceptibility of the Uygur children to caries.关键词
低龄儿童龋/人类白细胞抗原/基因多态性Key words
early childhood caries/human leucocyte antigen/genetic polymorphism分类
生物科学引用本文复制引用
张瑞涵,李小兵,王丽萍,刘奕杉..新疆维吾尔族和汉族儿童龋病与人类白细胞抗原-DQB1等位基因多态性的相关性研究[J].华西口腔医学杂志,2018,36(1):4-8,5.基金项目
国家自然科学基金(81560178)The National Natural Science Foundation of China (81560178). （81560178）
