华西口腔医学杂志2018，Vol.36Issue(1)：29-32,4.DOI:10.7518/hxkq.2018.01.006
富含脯氨酸的酪氨酸激酶2和磷酸化的丝氨酸/苏氨酸蛋白激酶在舌鳞状细胞癌组织中的表达及临床意义
Expression and clinical significance of proline-rich tyrosine kinase 2 and phospho-protein kinase B in tongue squamous cell carcinoma
摘要
Abstract
Objective This study aimed to investigate the expression and clinical significance ofproline-rich tyrosine kinase 2 (Pyk2) and phospho-protein kinase B (p-AKT) in tongue squamous cell carcinoma (TSCC) and adjacent nontumor tissues.Methods The Pyk2 and p-AKT protein levels were detected via immunohistochemistry in 45 cases of TSCC tissues and 30 cases of adjacent nontumor tissues.The relationships of the two protein levels and clinicopathological characteristics were also analyzed.Results Pyk2 and p-AKT levels were significantly higher in the TSCC tissues than in the adjacent nontumor tissues (P＜0.05).Nontumor tissues showed poor or no expression.The expression levels of the two proteins were positively correlated (γs=0.412).The expression of Pyk2 was associated with histopathological differentiation type,regional lymph node metastasis,and TNM staging (P＜0.05),but not with age and gender.The expression of p-AKT was only related to histopathological differentiation types (P＜0.05).Conclusion The abnormal expression of Pyk2 and p-AKT proteins might be closely related to the development and progression of TSCC.Joint detection can be used as an indicator to estimate the degree of TSCC.关键词
富含脯氨酸的酪氨酸激酶2/磷酸化的丝氨酸/苏氨酸蛋白激酶/舌鳞状细胞癌Key words
proline-rich tyrosine kinase 2/phospho-protein kinase B/tongue squamous cell carcinoma分类
生物科学引用本文复制引用
李玲玲,王升志,刘旭阳,刘浩,宫兆华..富含脯氨酸的酪氨酸激酶2和磷酸化的丝氨酸/苏氨酸蛋白激酶在舌鳞状细胞癌组织中的表达及临床意义[J].华西口腔医学杂志,2018,36(1):29-32,4.基金项目
国家自然科学基金(81071758) （81071758）
The National Natural Science Foundation of China (81071758). （81071758）
