华西口腔医学杂志2018，Vol.36Issue(1)：92-98,7.DOI:10.7518/hxkq.2018.01.018
头颈部肿瘤休眠机制的研究进展
Mechanisms and implications of cancer cell dormancy in head and neck carcinoma
摘要
Abstract
Disease metastasis and relapse in many cancer patients several years (even decades) after surgical remission have been recently acknowledged as cases of cancer dormancy.Although cases of minimal residual disease are well documented,knowledge on its biological mechanisms and clinical implications remains limited.To date,numerous reviews have summarized the three potential models that may explain this phenomenon,including the angiogenic,immunologic,and cellular dormancy.In this study,we discuss newly uncovered mechanisms goveming tumor cell dormancy in head and neck cancer,emphasizing on the crosstalk between dormant tumor cells and their microenvironments.Additionally,we explore the mechanisms on the reactivation of dormant residual tumor cells in anatomical sites,including the lymph nodes and bone marrow.关键词
肿瘤细胞休眠/播散肿瘤细胞/头颈部肿瘤/缺氧/淋巴结转移Key words
cancer dormancy/disseminated tumor cell/head and neck cancer/hypoxia/lymph-node metastasis分类
医药卫生引用本文复制引用
高晓磊,梁新华,汤亚玲..头颈部肿瘤休眠机制的研究进展[J].华西口腔医学杂志,2018,36(1):92-98,7.基金项目
国家自然科学基金(81772891)The National Natural Science Foundation of China (81772891). （81772891）
