计算机工程与应用2018，Vol.54Issue(6)：49-54,6.DOI:10.3778/j.issn.1002-8331.1611-0279
PPI网络比对用于植物乳杆菌的糖代谢研究
PPI network alignment for study on carbohydrate metabolism of Lactobacillus Plantarum
摘要
Abstract
Protein-Protein Interaction network(PPI network)alignment is an important method for predicting protein-protein interaction,and analyzing functional differences between different species.In this paper,in order to study the dif-ferences of the functional modules of the carbohydrate metabolism in Lactobacillus plantarum WCFS1 and JDM1,the PPI network of Glycolysis module, Pentose phosphate pathway module, Citrate cycle module in WCFS1 and JDM1 are aligned,by Evolutionary Graph Edit Distance Algorithm.Experiment shows that the Edge Correctness of three modules in WCFS1 and JDM1 reaches 93.6%,96%,100%,respectively.It indicates that the topological structure of the carbohy-drate metabolism module is very similar.And in pentose phosphate pathway of WCFS1 and JDM1,finding that WCFS1 has protein 2-keto-3-deoxygluconate kinase(kdgK)and JDM1 only has its product 2-keto-3-deoxy-6-phospho-gluconate aldolase(JDM1_0578)no kdgK.In addition,in Glycolysis module,inferring protein pyruvate dehydrogenase complex, E2 component(pdhC)and protein pyruvate kinase(pyk)have interaction.The experimental results show that PPI net-work alignment can clarify the differences of the carbohydrate metabolism module,topological similarity and can predict the interaction between proteins by aligning the PPI network.关键词
PPI网络比对/植物乳杆菌WCFS1和JDM1/糖代谢功能模块Key words
PPI network alignment/Lactobacillus plantarum WCFS1 and JDM1/carbohydrate metabolism functional modules分类
信息技术与安全科学引用本文复制引用
苗孟君,丁彦蕊..PPI网络比对用于植物乳杆菌的糖代谢研究[J].计算机工程与应用,2018,54(6):49-54,6.基金项目
国家自然科学基金(No.21541006). （No.21541006）
