实用临床医药杂志2018，Vol.22Issue(1)：4-6,3.DOI:10.7619/jcmp.201801002
重症脓毒症休克患者免疫状况的临床分析
Clinical analysis of immune status in patients with severe sepsis shock
摘要
Abstract
Objective To investigate the clinical immune status of patients with severe sepsis shock.Methods A total of 45 patients with sepsis in general ward and 45 severe sepsis shock patients treated in our hospital were selected for the study,and were as control group and observation group,respectively.The T lymphocyte,B lymphocyte and CD3+ CD4+,CD3+ CD8+,NK cells,immunoglobulin IgG,IgA,IgM levels,complement C3,C4 were detected in the two groups.The cellular immune function,humoral immune function and inflammatory reactions were compared between the two groups.Results The T lymphocyte count in the observation group and the control group were (60.0 ±16.2)％ and (77.2 ± 18.5)％,respectively,and The B lymphocyte count were (25.1 ± 10.2)％,and (14.3 ±6.9)％,respectively.The CD3+ CD8+ in the observation group was significantly lower,and CD4+/CD8+ was significantly higher than that in the control group (P ＜ 0.05).The percentage of NK cells and CD3 + CD8 + in the two groups showed no significant difference (P ＞ 0.05).The concentration of C4 and IgM in the observation group were significantly lower than that in the control group (P ＜ 0.05),and there was no significant difference between the two groups in C3,IgG and IgA (P ＞ 0.05).The WBC count,procalcitonin and C reactive protein in the observation group were significantly higher than that in the control group (P ＜ 0.05).Conclusion Severe septic shock patients have severe immune disorder.关键词
脓毒症休克/免疫紊乱/免疫球蛋白/NK细胞Key words
sepsis shock/immunity disorder/immunoglobulin/NK cells分类
医药卫生引用本文复制引用
孟祥忠,张晓宁,朱宇,张文旭..重症脓毒症休克患者免疫状况的临床分析[J].实用临床医药杂志,2018,22(1):4-6,3.基金项目
天津市卫生局科技计划项目(TW-2013B-224) （TW-2013B-224）
