检验医学与临床2017，Vol.14Issue(23)：3435-3437,3.DOI:10.3969/j.issn.1672-9455.2017.23.005
血清生长激素与胰岛素样生长因子1水平对脑部肿瘤鉴别诊断价值的探讨
The study of the diagnostic value of serum growth hormone and insulin-like growth factor 1 for brain tumors
摘要
Abstract
Objective To explore the diagnostic value of serum growth hormone(GH) and insulin-like growth factor 1 (IGF-1) for brain tumors.Methods Seven hundred and twenty-one serum samples from the inpatients of neurosurgery in Beijing Tiantan hospital were collected,and were divided into three groups including pituitary tumor group,benign tumor group,and malignant tumor group according to pathological findings.Sixty-two serum samples from the health check-up people were set as control group.The levels of serum GH and IGF-1 were detected,and the diagnostic value was discussed.Results The levels of GH and IGF-1 in patients with pituitary tumor,benign tumor,malignant tumor and healthy individuals had statistical significance(P＜ 0.05).The levels of GH and IGF-1 in pituitary tumor group were significantly higher than pituitary tumor group and control group,and there was a correlation between the levels of GH and IGF-1(P＜0.05).The levels of GH and IGF-1 were decreased after the operation.By making receiver operating characteristic curve,we found that the cut-off values of GH and 1GF-1 for diagnosing pituitary tumor were 3.535 ng/mL and 277.000 ng/mL,and the specificities were 96.77％ and 100.00％.For other brain tumors,the trend of GH levels from high to low were malignant tumor group,benign tumor group and control group.There were significant differences between malignant tumor group with benign tumor group,and malignant tumor group with control group(P＜0.012 5).The levels of IGF-1 from high to low in these group were malignant tumor group,control group and benign tumor group.The levels of IGF-1 in malignant tumor group and benign tumor group were significantly different(P＜0.012 5),but there was no significant difference among other groups(P＞0.012 5).Conclusion The levels of serum GH and IGF-1 could be used as important exclusion indexes for diagnosing pituitary tumor.For other brain tumors,the levels of serum GH and IGF-1 go up with the increase of malignance.关键词
生长激素/胰岛素样生长因子1/脑部肿瘤/垂体瘤Key words
growth hormone/insulin-like growth factor 1/brain tumor/pituitary tumor引用本文复制引用
马瑞敏,贾子琪,康熙雄,司学众,张国军..血清生长激素与胰岛素样生长因子1水平对脑部肿瘤鉴别诊断价值的探讨[J].检验医学与临床,2017,14(23):3435-3437,3.基金项目
北京市优秀人才青年拔尖个人资助项目(2015000021223ZK34). （2015000021223ZK34）
