检验医学与临床2017，Vol.14Issue(23)：3444-3446,3.DOI:10.3969/j.issn.1672-9455.2017.23.008
化脓链球菌致中毒性休克综合征临床分析
Analysis of toxic shock syndrome caused by Streptococcus pyogenes
摘要
Abstract
Objective To reveal the laboratory characteristics of toxic shock syndrome STSS) caused by Streptococcus pyogenes,and to provide new evidences for clinical diagnosis and epidemiological investigation.Methods We retrospectively reviewed a case with STSS caused by Streptococcus pyogenes,including the course of diagnosis and therapy,laboratory data,emm genotyping for the isolate,and the superantigen detection.Results The patient suffered from a severe infection on the left lower limb due to skin ulceration of her left toes,accompanied by multiple organ failure and STSS.Streptococcus pyogenes strains were isolated from the wound secretion;the isolates were sensitive to penicillin.The genotype was emm1.1,carrying genes for superantigens,including speA,speC,spek,ssa and smeZ.The therapeutic strategy for the patient included debridement,vacuum sealing drainage,and penicillin combined with clindamycin for infection control.The symptoms were improved obviously.Conclusion The severe clinical symptoms of STSS caused by Streptococcus pyogenes may associate with the superantigen gene carried by the isolate.Surgical treatment and infection control may play a vital role in patients whose features similar with this case.关键词
化脓链球菌/中毒性休克综合征/emm基因/超抗原Key words
Streptococcus pyogenes/toxic shock syndrome/emm gene/superantigen引用本文复制引用
宁兴旺,朱惠斌,钱纯,邓兰平,谢小兵..化脓链球菌致中毒性休克综合征临床分析[J].检验医学与临床,2017,14(23):3444-3446,3.基金项目
湖南省教育厅科学研究资助项目(17B195). （17B195）
