检验医学与临床2017，Vol.14Issue(23)：3509-3511,3514,4.DOI:10.3969/j.issn.1672-9455.2017.23.030
系统性红斑狼疮伴真菌感染的病原学特点、耐药性及危险因素分析
Pathogenic characteristics, drug resistance and risk factors of systemic lupus erythematosus with fungal infection
郭向华 1李健 1张丽丽 1邵莉 1毛玉景 1宋芹1
作者信息
- 1. 济宁医学院附属医院风湿免疫科,山东济宁272029
- 折叠
摘要
Abstract
Objective To explore pathogenic characteristics,drug resistance and risk factors of systemic lupus erythematosus with fungal infection.Methods Clinical data of 78 cases of patients with systemic lupus erythematosus with fungal infection treated in the hospital were analyzed retrospectively.Pathogenic bacteria and drug resistance test were carried out,and related factors of influencing systemic lupus erythematosus with fungal infection were analyzed with multi factors Logistic regression.Results Among 554 cases of patients with systemic lupus erythematosus in the study,78 cases were with fungal infection,accounting for 14.08％.The incidence rates of respiratory tract,urinary tract infection were 29.49 ％ and 25.64％ respectively.And in 78 cases of fungal culture results,a total 102 strains of fungal were found out,including Candida albicans and Staphylococcus aureus,which accounted for 52.94％ and 31.37％.Multi Logistic regression analysis showed independent risk factors which influenced the infection were hospitalization time longer than 4 weeks,24 h urinary protein more than or equal to 3.5 g,the number of organ damage involving more than or equal to 3,antibiotic applied time more than or equal to two weeks,the white blood cell count over 3 × 109/L,CD4+ lower than 200 per microliter and complement C3 lower than 0.8 mg/L.Conclusion There are many factors influencing systemic lupus erythematosus with fungal infection,and the clinic should base on infection location and fungal infection types to improve the effect.Meanwhile,it should strengthen prevention according to the influencing factors,so as to reduce the infected incidence.关键词
系统性红斑狼疮/真菌感染/病原学/耐药性/Logistic回归分析Key words
systemic lupus erythematosus/fungal infection/etiology/drug resistance/Logistic regression analysis引用本文复制引用
郭向华,李健,张丽丽,邵莉,毛玉景,宋芹..系统性红斑狼疮伴真菌感染的病原学特点、耐药性及危险因素分析[J].检验医学与临床,2017,14(23):3509-3511,3514,4.
