检验医学与临床2017，Vol.14Issue(23)：3515-3516,3519,3.DOI:10.3969/j.issn.1672-9455.2017.23.032
HIF-1α、Glut-1及VEGF在皮肤鳞状细胞癌及基底细胞癌中的表达
Expression of HIF-1α,Glut-1 and VEGF in squamous cell carcinoma and basal cell carcinoma
杨今言 1闫军 2龚晓瑾 3陈赵慧 1卢娟 1李丽华 1宋珍珍1
作者信息
- 1. 新疆医科大学第二附属医院皮肤科,乌鲁木齐830064
- 2. 新疆医科大学第二附属医院普外科,乌鲁木齐830064
- 3. 新疆医科大学第二附属医院病理科,乌鲁木齐830064
- 折叠
摘要
Abstract
Objective To investigate the expression of hypoxia-inducioble factor-1α(HIF-1α),glucose transporter-1 (Glut-1) and vascular endothelial growth factor(VEGF) in squamous cell carcinoma(SCC) and basal cell carcinoma(BCC).Methods The expression of HIF-1α,Glut-1 and VEGF was used to detected by immunohistochemistry in 43 cases of SCC,109 cases of BCC and 30 cases of normal skin tissue,and to analyze the correlation between them.Results The expression of HIF 1α,Glut-1 and VEGF in SCC and BCC tissue was significantly higher than that in normal skin tissue(P＜(0.05).The expression of HIF-1α,Glut-1 and VEGF in SCC tissue was significantly higher than that in BCC tissue(P＜0.05).The expression of HIF 1α,Glut-1 and VEGF in SCC tissue was not correlated with the degree of tumor differentiation.The expression of HIF-1α,Glut-1 and VEGF presented positive correlation with each other(P＜0.05).Conclusion HIF-1α,Glut-1 and VEGF are highly expressed in SCC and BCC,and the expression of three indicators could provide a basis for the diagnosis of SCC and BCC.关键词
缺氧诱导因子-1α/葡萄糖转运蛋白-1/血管内皮生长因子/皮肤鳞状细胞癌/基底细胞癌Key words
hypoxia-inducioble factor-1α/glucose transporter-1/vascular endothelial growth factor/squamous cell carcinoma/basal cell carcinoma引用本文复制引用
杨今言,闫军,龚晓瑾,陈赵慧,卢娟,李丽华,宋珍珍..HIF-1α、Glut-1及VEGF在皮肤鳞状细胞癌及基底细胞癌中的表达[J].检验医学与临床,2017,14(23):3515-3516,3519,3.
