检验医学与临床2018，Vol.15Issue(5)：577-579,582,4.DOI:10.3969/j.issn.1672-9455.2018.05.001
血清学指标结合ESSDAI在原发性干燥综合征中的临床价值
Clinical value of serum markers combined with ESSDAI in primary Sjogren syndrome
摘要
Abstract
Objective To investigate the clinical value of serum index combined with EULAR Sjogren syn-drome disease activity index(ESSDAI)in primary Sjogren syndrome(SS).Methods From February 2013 to December 2016,68 patients with SS in our hospital were selected as the SS group,and another 68 healthy peo-ple in our hospital physical examination were selected as the control group,two groups were tested with ESS-DAI score and serum index[IL-27,IL-10,1,25(OH)2D],and the correlation analysis was conducted.Results The ESSDAI score of SS group was 14.21 ± 1.03,which was significantly higher than that of the control group of 1.87 ± 0.45(t=13.224,P<0.05).The values of IL-10,IL-27,1,25(OH)2D in the sera of SS group were(158.33 ± 32.19)pg/mL,(84.33 ± 14.29)pg/mL and(8.42 ± 2.49)ng/mL,in contrast to(37.44 ± 14.92)pg/mL,(23.11 ± 1.94)pg/mL and(34.10 ± 3.41)ng/mL in the control group,respectively.There was statistically significant difference compared between the two groups(P<0.05).Spearman correlation analysis showed that the ESSDAI score were positively correlated with IL-10 and IL-27(P<0.05),and showed signif-icant negatively correlated with 1,25(OH)2D(P<0.05).Multivariate logistic regression analysis showed that IL-10,IL-27,1,25(OH)2D were the main risk factors that affected ESSDAI score(P<0.05).Conclusion ES-SDAI is a common index to evaluate the SS patients'condition.SS patients have obvious abnormal serum IL-10,IL-27 and 1,25(OH)2D levels which shows reciprocal interactions with ESSDAI score,which can be evalu-ated together for better applicable implications.关键词
干燥综合征疾病活动指数/白细胞介素/干燥综合征Key words
Sjogren syndrome disease activity index/interleukin/Sjogren syndrome分类
医药卫生引用本文复制引用
周丽芳,姜帆,王媛,吴广明,曾玮..血清学指标结合ESSDAI在原发性干燥综合征中的临床价值[J].检验医学与临床,2018,15(5):577-579,582,4.基金项目
北京市科技计划课题项目(z151100007879134). （z151100007879134）
