检验医学与临床2018，Vol.15Issue(5)：586-588,3.DOI:10.3969/j.issn.1672-9455.2018.05.004
依托泊苷与拓扑替康对小细胞肺癌患者的远期预后及LincRNA水平的影响
Effects of etoposide and topotecan on long-term prognosis and LincRNA of patients with small cell lung cancer
摘要
Abstract
Objective To investigate the effect of etoposide combined with cisplatin(EP regimen)and to-potecan combined with cisplatin(TP regimen)on the prognosis and level of long intergenic non-coding RNAs (LincRNA)of patients with small cell lung cancer(SCLC).Methods Sixty-two patients with SCLC were ran-domly divided into two groups:EP group and TP group.The patients were treated with chemotherapy regi-men.The curative effect,prognosis and LincRNA MEG3 levels of the two groups were compared before and after treatment.Pearson correlation was used to analyze the relationship between MEG 3 and prognosis of pa-tients.Results The objective response rate of patients in the EP group was 71.0%,and the progression-free survival time and the overall survival time of the patients in the EP group were(5.3 ± 2.2)months and(8.8 ± 3.5)months.T he objective response rate,the progression-free survival time and the overall survival time of the TP group were 64.5%,(5.6 ± 2.3)months and(9.0 ± 3.7)months,respectively.The differences of the indica-tors between the two groups were not statistical significant(P>0.05).There was no significant difference in the incidence of complications such as anemia,thrombocytopenia,nausea and vomiting,and liver function ab-normality(P>0.05).The serum LincRNA MEG3 level in patients with longer survival time was significantly than patients in short survival time patients(P<0.05).Pearson analysis showed a negative correlation be-tween serum LincRNA MEG3 levels and survival time(r= -0.356,P<0.05).Conclusion EP regimen and TP regimen have similar effects on patients with SCLC,with no different effect on prognosis,no difference in adverse reactions.Serum LincRNA MEG3 levels are correlated with prognosis of patients,which can be used as an effective indicator of prognosis.关键词
依托泊苷/拓扑替康/小细胞肺癌/长链非编码RNA/预后Key words
etoposide/topotecan/small cell lung cancer/long intergenic non-coding RNAs/prog-nosis分类
医药卫生引用本文复制引用
王刚,吕金燕,王若雨,赵婧,刘莹,唐荣彬..依托泊苷与拓扑替康对小细胞肺癌患者的远期预后及LincRNA水平的影响[J].检验医学与临床,2018,15(5):586-588,3.基金项目
辽宁省卫生和计划生育委员会项目(2016C475). （2016C475）
