检验医学与临床2018，Vol.15Issue(5)：592-595,4.DOI:10.3969/j.issn.1672-9455.2018.05.006
胸腺五肽联合连花清瘟胶囊对AECOPD患者的疗效及其对免疫功能的影响
Effects of thymopentin combined with Lianhua Qingwen capsule on AECOPD patients and its influence on immune function
摘要
Abstract
Objective To investigate the effect of thymopentin combined with Lianhua Qingwen capsule on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients and its influence on immune function.Methods From June 2016 to July 2017,100 patients with AECOPD in our hospital were selected for group study.All the patients were divided into the observation group(n=60)and the control group(n=40) according to the random grouping method.The control group was treated with thymus five peptide,and the observation group was treated with thymopentin combined with Lianhua Qingwen capsule.The clinical effica-cy,pulmonary function index,blood gas index,immune function,inflammatory factors and adverse reactions were compared between the two groups.Results The total effective rate of the observation group(96.7%) was significantly higher than that of the control group(70.0%)(P<0.05).The FEV1%,FEV1/FVC% and pO2in the observation group were significantly higher than that in the control group(P<0.05),and the pCO2 was significantly lower than that in the control group(P<0.05).The improvement of CD4+,CD8+,CD4+/CD8+and IgG in the observation group was significantly better than that in the control group(P<0.05).The levels of IL-6,IL-8 and TNF-α in the observation group were significantly lower than those in the control group(P<0.05).There was no significant differences in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The curative effect of thymopentin combined with Lianhua Qingwen capsule in the treatment of AECOPD is exact,which could significantly improve the pulmonary function and immune function,and effectively reduce the inflammatory level.关键词
胸腺五肽/连花清瘟胶囊/慢性阻塞性肺疾病/免疫功能Key words
thymopentin/Lianhua Qingwen capsule/chronic obstructive pulmonary disease/immune function分类
医药卫生引用本文复制引用
白容,杨超..胸腺五肽联合连花清瘟胶囊对AECOPD患者的疗效及其对免疫功能的影响[J].检验医学与临床,2018,15(5):592-595,4.基金项目
重庆市江北区科技计划项目(20160208). （20160208）
