临床肝胆病杂志2018，Vol.34Issue(2)：229-232,4.DOI:10.3969/j.issn.1001-5256.2018.02.002
慢性丙型肝炎直接抗病毒药物的相互作用
Drug-drug interaction of direct-acting antivirals in treatment of chronic hepatitis C
汪梦兰 1唐红1
作者信息
- 1. 四川大学华西医院感染性疾病中心,成都610041
- 折叠
摘要
Abstract
With the successful application of direct-acting antivirals (DAAs) in the treatment of hepatitis C,clinical management of drug -drug interaction (DDI) has become a hot topic in this field.Most DAAs develop DDI with other drugs administered at the same time via cytochrome P450 or transporters in the liver and/or the intestine.At present,European Association for the Study of the Liver has published the recommendations on DDI of DAAs in the treatment of chronic hepatitis C,which covers HIV antiretrovirals,lipid-lowering drugs,cardiovascular drugs,immunosuppressants,and addictive drugs for the central nervous system.When developing the regimens for DAA treatment,clinicians should closely assess and monitor the risk of DDI,in order to reduce or avoid treatment failure or adverse reactions during antiviral therapy.关键词
肝炎,丙型,慢性/抗病毒药/药物相互作用Key words
hepatitis C, chronic/antiviral agents/drug interactions分类
医药卫生引用本文复制引用
汪梦兰,唐红..慢性丙型肝炎直接抗病毒药物的相互作用[J].临床肝胆病杂志,2018,34(2):229-232,4.
