临床肝胆病杂志2018，Vol.34Issue(2)：281-286,6.DOI:10.3969/j.issn.1001-5256.2018.02.013
单采血浆后自身抗体阳性慢性丙型肝炎患者肝组织的病理学特点
Pathological features of liver tissue in autoantibody-positive chronic hepatitis C patients after plasmaphoresis
摘要
Abstract
ObjectiveTo investigate the detection rate and features of autoantibodies in chronic hepatitis C (CHC) patients after plasmaphoresis,as well as the liver pathological features of autoantibody-positive CHC patients.Methods A total of 120 patients who were infected with hepatitis C virus after plasmaphoresis in the Hospital of Dingxi County and Dingxi Hospital of Infectious Diseases from January 1992 to December 1995 were selected as test group;11 healthy people from the same region were selected as control group.Autoantibody detection was performed for the 120 CHC patients,and liver pathological features were compared between the autoantibody-positive group (n =44) and autoantibody-negative group (n =76) of these patients.The t test was used for comparison of continuous data,and the chi-square test was used for comparison of categorical data.Results Of all 120 CHC patients who underwent plasmaphoresis,44 (36.7％) were found to have serum autoantibodies,with antinuclear antibodies as the most common type (21.7％).Compared with the autoantibody-negative group,the autoantibody-positive group had significantly higher scores of focal necrosis inside the hepatic lobules (2.11 ±0.88 vs 1.64 ± 0.88,t =2.349,P =0.021) and ductular reaction inside the portal area (1.86 ±0.71 vs 1.13 ±0.66,t =4.217,P ＜0.001),as well as a significantly higher rate of interlobular bile duct injury (86.4％ vs 55.3％,x2 =12.129,P =0.001).There were no significant differences between the two groups in the degree of liver fibrosis and hepatic steatosis (both P ＞ 0.05).Conclusion Autoantibody-positive are common in CHC patients after plasmaphoresis,and autoantibody-positive patients tend to have more severe injuries of the liver.关键词
血浆/肝炎,丙型,慢性/自身抗体/病理状态,体征和症状Key words
plasma/hepatitis C, chronic/autoantibodies/pathological conditions, signs and symptoms分类
医药卫生引用本文复制引用
伍慧丽,段钟平,郑素军,王泰龄,闫惠平,任峰,李俊峰,陈煜,刘梅,刘霜..单采血浆后自身抗体阳性慢性丙型肝炎患者肝组织的病理学特点[J].临床肝胆病杂志,2018,34(2):281-286,6.基金项目
2017年度创新基地培育和发展专项(Z171100002217070) （Z171100002217070）
