陈婧 1刘晓燕 1童晶晶 1张丽娜 1关崇丹 1严立龙 1胡瑾华 1苏海滨1
作者信息
- 1. 解放军第三○二医院肝衰竭中心,北京100039
- 折叠
摘要
Abstract
Objective To evaluate the clinical features of patients with acute/subacute liver failure (ALF/SALF) complicated by acute kidney failure (AKI).Methods A retrospective analysis was performed for the clinical data of 115 ALF/SALF patients who were admitted to 302 Hospital of PLA from January.2015 to December 2016,and according to the presence or absence of AKI,these patients were divided into AKI group with 36 patients and non-AKI group with 79 patients.The two groups were compared in terms of age,sex,liver function,peripheral white blood cell count (WBC),coagulation function,Model for End-Stage Liver Disease (MELD) score,and complications,and the prognosis of AKI patients was also observed.The t-test was used for comparison of continuous data between groups,and the chi-square test was used for comparison of categorical data between groups.Results The most common cause of ALF/SALF was drug (49.57％),followed by unknown causes (28.70％).Of all 115 ALF/SALF patients,36 had AKI,resulting in an incidence rate of 31.3％,and the incidence rates of stage 1,2,and 3 AKI were 11.30％,14.78％,and 5.22％,respectively.Compared with the non-AKI group,the AKI group had significantly higher age,WBC,neutrophil ratio,incidence rates of ascites and abdominal/pulmonary infection,and MELD score (all P ＜0.05),as well as a significant reduction in the serum level of albumin (P ＜0.05).The AKI group had a significantly higher rate of no response/death than the non-AKI group (69.4％ vs 38.0％,x2 =9.815,P =0.002),and the mortality rate increased with the increase in the severity of AKI.Among the patients with stage 1,2,and 3 AKI,61.5％,70.6％,and 83.3％,respectively,had no response or died.Conclusion Most of the patients with liver failure complicated by AKI have infections or inflammatory response,and the development of AKI is associated with the mortality of patients with liver failure.关键词
肝功能衰竭/肾疾病/疾病特征Key words
liver failure/kidney diseases/disease attributes分类
医药卫生
