临床肝胆病杂志2018，Vol.34Issue(2)：403-406,4.DOI:10.3969/j.issn.1001-5256.2018.02.041
HCV感染者抗病毒治疗前后免疫状态的变化
Change in immune status after antiviral therapy in patients with hepatitis C virus infection
摘要
Abstract
Hepatitis C virus (HCV) infection is a global public health issue.At present,pegylated interferon (IFN) combined with ribavirin is the major therapeutic regimen for anti-HCV treatment in China,but this regimen cannot achieve ideal sustained virologic response.Direct-acting antivirals (DAA) have achieved marked clinical effects in the treatment of patients with hepatitis C.This article briefly describes the change in immune status after anti-HCV treatment from the three aspects of innate immunity,adaptive immunity,and cytokines/ chemokines.The analysis shows that HCV patients have complex immunoregulation,and the results vary from one study to another.In general,the expression of NK cell surface receptor and its function tend to recover and may even recover to a normal state.IFN treatment cannot restore the function of virus-specific CD8 + T lymphocytes,while the change in cytotoxic T lymphocytes after DAA treatment has not been clarified.Further studies are needed to elucidate the long-term effect of DAA on cvtokines and chemokines.关键词
抗病毒药/肝炎,丙型/免疫/综述Key words
antiviral agents/hepatitis C/immunity/review分类
医药卫生引用本文复制引用
蒋莹莹,张晓慧,郑素军..HCV感染者抗病毒治疗前后免疫状态的变化[J].临床肝胆病杂志,2018,34(2):403-406,4.基金项目
北京市科学技术委员会资助临床特色项目(Z131107002213019,Z151100004015066) （Z131107002213019,Z151100004015066）
国家自然科学基金(81500472) （81500472）
