临床眼科杂志2018，Vol.26Issue(1)：1-4,4.DOI:10.3969/j.issn.1006-8422.2018.01.001
玻璃体腔注射雷珠单抗联合光动力疗法治疗息肉状脉络膜血管病变的临床观察
Clinical observation on the treatment of polypoidal choroidal vasculopathy with intravitreal ranibizumab in-jection and photodynamic therapy
摘要
Abstract
Objective To investigate the clinical efficacy of combined intravitreal ranibizumab injection and photo -dynamic therapy(PDT)in the treatment of polypoid choroidal vasculopathy(PCV).Methods Clinical data of 15 pa-tients(16 eyes)diagnosed with PCV were retrospectively studied.All patients were examined with optical coherence tomo-graphy(OCT),indocyanine green angiography(ICGA)and fundus fluorescein angiography(FFA),fundus color photog-raphy and visual inspection.They were injected with ranibizumab(0.5mg /0.05 ml)before PDT therapy and were fol-lowed up for 6 months.Central retina thickness(CRT),vision changes,macular hemorrhage absorption and polypoidal le-sions were analyzed.Results Average visual acuity before treatment was 0.92 ±0.62 logMAR and significantly improved to 0.53 ±0.27 logMAR after treatment(t =2.416,P <0.05).Average CRT was 358.17 ±141.29 μm before treatment and decreased to 218.29 ±50.23 μm at 6 months after treatment(t =4.492,P <0.05).FFA and ICGA showed that in 3 eyes(18.8%)there was a decrease in polypoidal lesions,and there were 13 eyes(81.2%)showed complete regression of the polypoidal lesions.Conclusions Intravitreal injection of ranibizumab combined with photodynamic therapy for pol -ypoidal choroidal vasculopathy has good clinical results and significantly improves visual acuity and retinal edema.It is wor-thy of promotion in clinical use.关键词
息肉状脉络膜血管病变/玻璃体腔注射/雷珠单抗/光动力治疗/临床观察Key words
Polypoidal choroidal vasculopathy/Vitreous cavity/Monoclonal antibody/Photodynamic therapy/Clinical observation引用本文复制引用
赵燕,吴建华,严立..玻璃体腔注射雷珠单抗联合光动力疗法治疗息肉状脉络膜血管病变的临床观察[J].临床眼科杂志,2018,26(1):1-4,4.
