临床眼科杂志2018，Vol.26Issue(1)：36-38,3.DOI:10.3969/j.issn.1006-8422.2018.01.010
组织工程口腔黏膜移植治疗重症眼表烧伤
Tissue-engineered oral mucosal epithelial cells to reconstruct ocular surface in patients with severe corneal burn
杨子建1
作者信息
- 1. 201800 上海交通大学医学院附属瑞金医院北院眼科
- 折叠
摘要
Abstract
Objective Severe ocular surface diseases often lead to disruption of the corneal surface by invading neighboring conjunctival epithelial cells.Since there are no healthy conjunctival epithelia,cornea epithelia and limbal epi-thelia available for auto transplantation,ocular surface reconstruction is difficult.This study tried to evaluate clinical effica-cy of using tissue-engineered oral mucosal epithelial cells for ocular surface reconstruction.Methods Eight eyes of seven patients with severe ocular surface damage due to thermal or chemical burns were treated with tissue -engineered oral muco-sal epithelial cells.Corneal leukoma,fibrous tissues and neovascularization tissues were excised completely.Tissue-engi-neered oral mucosal epithelial cells on the amnions were transplanted to each eye.Visual acuity, corneal surface erosions and symptoms were observed to evaluate the effect.Results Corneas in all 8 eyes were epithelized and became more pellu-cid after surgery.The structure of ocular surface in all corneas was recovered to various degrees.Scars and fibroplastic pro-liferation of corneas decreased and symblepharon was relieved.Postoperative BCVA of one eye was 20/100 and others were finger count.Conclusions Ocular surface reconstruction of severe ocular injury is a difficult task.Using the cultivated mucosal epithelial transplantation improves visual outcome and structural and functional recovery of ocular surface.关键词
口腔黏膜上皮/角膜/移植/眼表重建Key words
Cultivated mucosal epithelia/Cornea/Transplantation/Ocular surface reconstruction引用本文复制引用
杨子建..组织工程口腔黏膜移植治疗重症眼表烧伤[J].临床眼科杂志,2018,26(1):36-38,3.
