兽类学报2017，Vol.37Issue(3)：300-307,8.DOI:10.16829/j.slxb.201703011
啮齿目核糖酸酶5基因(RNase5)的分子进化
Molecular evolution of the RNase5 in Rodentia
摘要
Abstract
RNase5 is an important member of the RNASE A superfamily.It has been considered as an intriguing model in molecular evolution studies.17 species belong to 10 families from three evolution branches of Rodentia are analysised.RNase5 is detected in each genome by TBlastN and BlastN,which suggest the gene is losted in all species of Ctenohystrica after the evolution clade formed.Reconstructed RNase5 trees based on both Neighbor-Joining and Maximum likelihood methods supported three independent gene duplications are observed in Mus Musculus,Rattus norvegicus and Peromyscus maniculatus in the mouse-related clade suborder.Strong positive selection was detected in the branch model,site model and branch-site model of PAML.In sum,the present work demonstrated the diversity about RNase5 studies,that provides an important foundation for further studies adaptive evolution mechanism of the RNase5.关键词
啮齿目/RNase5/分子进化/基因复制/正选择Key words
RNase5/Molecular evolution/Gene duplication/Positive selection/Rodentia分类
生物科学引用本文复制引用
郎大田,张新军,吴银梅..啮齿目核糖酸酶5基因(RNase5)的分子进化[J].兽类学报,2017,37(3):300-307,8.基金项目
云南省科技厅应用基础研究项目(Y0120160118) （Y0120160118）
云南省教育厅指导性项目(2017ZDX037) （2017ZDX037）
中国科学院昆明动物研究所遗传资源与进化国家重点实验室开放课题(GREKF17-02) （GREKF17-02）
