天然产物研究与开发2018，Vol.30Issue(1)：109-113,5.DOI:10.16333/j.1001-6880.2018.1.019
荔枝草提取物治疗慢性咽炎的作用及机制研究
Study on the Effect and Mechanism of Extract of Saluia plebeia R.Br.on Chronic Pharyngitis
摘要
Abstract
In order to provide the reference for the clinical utilization of Saluia plebeia R.Br.,this paper investigated the anti-chronic pharyngitis activity and mechanism of Saluia plebeia R.Br.ethyl acetate extract,based on screening of the anti-inflammatory active fractions from Saluia plebeia R.Br.After establishing the chronic pharyngitismodel in rats by ammonia stimulation,this paper explored the praxiology,pharynx pathological observation and double-antibody sandwich ELISA of the model rats which were treated in different dosing of Saluia plebeia R.Br.ethyl acetate extract.The model of chronic pharyngitis in ratswas consistent with the chronic pharyngitis features.HE staining sections showed that Saluia plebeia R.Br.ethyl acetate extract could significantly improve the pathological morphology of pharynx.Compared with the model group,the levels of ILβ、IL-6β、ICAM-1 、TNF-α and CRP in the serum of treatment group rats were decreased in different degrees,with the most significant in the high-dose group.The results indicated that the ethyl acetate extract of Saluia plebeia R.Br.owned therapeutic effect on chronic pharyngitis.The therapeutic effect is related to the level of lymphocytes and inflammatory factors in the blood,and improved the level of lymphocytes and inflammatory factors.关键词
荔枝草/提取物/慢性咽炎/作用/机制Key words
Saluia plebeia R.Br./extract/chronic pharyngitis/effect/mechanism分类
生物科学引用本文复制引用
孔庆新,东方,李思阳,钱俊,曲中原,邹翔,姜雪,李雪..荔枝草提取物治疗慢性咽炎的作用及机制研究[J].天然产物研究与开发,2018,30(1):109-113,5.基金项目
淮安市科技计划(工业):淮安特色中药荔枝草治疗慢性咽炎作用机制研究及其系列产品开发(HAG201613) （工业）
