天然产物研究与开发2018，Vol.30Issue(1)：161-167,7.DOI:10.16333/j.1001-6880.2018.1.027
黄芪及其药效成分干预肺纤维化相关作用机制的实验研究进展
Experimental Research Progress on the Intervention Mechanism of Astragali Radix and Its Medicinal Composition on Pulmonary Fibrosis
摘要
Abstract
Astragali Radix had abundant nedicinal compositions of saponins,flavonoids,polysaccharides and trace elements.A present hotspot was experiment mechanism study of Astragali Radix and its medicinal compositions on pulmonary fibrosis (PF),including astragalus polysaccharide (APS),astragaloside Ⅳ (AST),cycloastragenol (CAG),total saponins of astragalus (TSA),total flavonoids of astragalus (TFA),and watery extract of astragalus (WEA).A large number of domestic and foreign studies focused on revealling the intervention mechanism of Astragali Radix and its medicinal compositions on PF from the perspective of regulating signal transduction pathways,regulating key factors and gene expression of cell differentiation,regulating oxidative stress (OS) response,regulating inflammatory response,improving histomorphology,activating telomerase,and regulating extracellular matrix (ECM) and matrixmetalloproteinases.However,most studies of them only investigated the single factor or signal pathway,and lacked of attention to network regulation relationship of multiple mechanisms.Based on multi-level,multi-angle and systematic biology,the study of intervention mechanism and treatment target of Astragali Radix and its medicinal compositions on PF should be the research emphasis in follow-up study.关键词
黄芪/药效成分/肺纤维化/作用机制/实验研究Key words
Astragali Radix/medicinal compositions/pulmonary fibrosis/mechanism of action/experimental study分类
医药卫生引用本文复制引用
顾志荣,李芳,葛斌..黄芪及其药效成分干预肺纤维化相关作用机制的实验研究进展[J].天然产物研究与开发,2018,30(1):161-167,7.基金项目
甘肃省人民医院青年科研项目(16GSSY7-2) （16GSSY7-2）
国家自然科学基金(81260597) （81260597）
甘肃省中医药管理局科研项目(GZK-2015-45) （GZK-2015-45）
