现代妇产科进展2018，Vol.27Issue(3)：179-181,3.DOI:10.13283/j.cnki.xdfckjz.2018.03.005
13042例孕妇早期产前筛查的研究分析
A study of first-trimester screening of 13042 pregnant women
杨微微 1任晨春 1王文靖 1梁玥宏 1李德明 1张海霞 1张月香1
作者信息
- 1. 天津市中心妇产科医院检验科,天津 300100
- 折叠
摘要
Abstract
Objective:To evaluate the role of serological screening for first trimester and reduce the birth rate of the chromosomal abnormalities fetus. Methods:Pregnancy associat-ed plasma protein A ( PAPP A) andβ-human chorionic gonadotropin ( beta HCG) in peripher-al blood of pregnant women were quantitatively analyzed,first-trimester fetal nuchal translucen-cy thickness(NT) and pregnant women's age,body mass and gestational age were also meas-ured. We used LifeCycle4. 0 software and all the results above to evaluate the occurrence of tri-somy syndrome. The karyotype analysis of villi or amniotic fluid cell were detected for the high-risk patients. Results:373 cases(3. 00％) were screen-positive in 13042 cases. For high risks of trisomy 21 pregnancies,the measured multiple of the median ( MoM) values on average for PAPP-A was 0. 98,the free beta HCG was 2. 218,and NT was 2. 56. For high risks of trisomy 18 pregnancies,the MoM values on average for PAPP-A was 0. 647, the free beta HCG was 1 . 847 , and NT was 3 . 07 . Chromosome karyotype analysis were detected in 248 patients (66. 5％) in pregnant women who got the positive results for first trimester screening. 58 cases found abnormal chromosomes(23. 4％). Among them,30 cases were trisomy 21,7 cases were trisomy 18,3 cases were trisomy 13,8 were sexual chromosome abnormality,7 cases were chi-mera,and 3 cases were multiploid. The true screen-positive rates of age over 35 years and under 35 years were 14 . 8％ and 34 . 9％. Conclusion:Chromosomal abnormalities fetus could be found by serological screening for first trimester. And it could be used to reduce the incidence of birth defects. They should be routinely screened for pregnant women of age under 35 years.关键词
孕早期筛查/妊娠相关蛋白/游离人绒毛膜促性腺激素/颈项透明膜厚度/染色体核型Key words
First-trimester screening/Pregnancy-associated plasma protein A/β-hu-man chorionic gonadotropin/Nuchal translucency/Chromosome karyotype分类
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杨微微,任晨春,王文靖,梁玥宏,李德明,张海霞,张月香..13042例孕妇早期产前筛查的研究分析[J].现代妇产科进展,2018,27(3):179-181,3.
