眼科新进展2018，Vol.38Issue(2)：156-160,5.DOI:10.13389/j.cnki.rao.2018.0035
单酰甘油酰基转移酶2(MOGAT2)在翼状胬肉组织中的表达及意义
Expression and significance of monoacylglycerol Oacyltransferase 2 (MOGAT2) in pterygium
秦柏 1黄剑飞 2张俊芳 1朱惠君 2杨梅 1杨铃 1钱晶晶 1梁舒 1吴玉宇 1陆宏1
作者信息
- 1. 226001 江苏省南通市,南通大学附属医院眼科
- 2. 226001江苏省南通市,南通大学附属医院病理科
- 折叠
摘要
Abstract
Objective To investigate the expression and significance of monoacylglycerol O-acyltransferase 2 (MOGAT2) in the tissues of pterygium.Methods Immunohistochemistry staining methods were adopted to detect the expression of MOGAT2 in 54 patients of pterygia (primary in 50 patients and recurrence in 4 patients)and 18 patients of normal conjunctival tissues.The semi-quantitative integration method was used to analyze the strength of immunohistochemical expression,and the results were compared and statistically analyzed,and the relationship between the expression of MOGAT2 in the pterygium group and the factors such as age,sex,and clinical pathological stage was analyzed.Results Immunohistochemical staining showed that,in 54 patients of pterygium,MOGAT2 was strongly expressed in 8 patients,positive expression in 29,weakly positive expression in 8 and negative expression in 9,while in 18 normal conjunctival tissues,strongly positive expression of MOGAT2 was found 1 patient,positive expression in 6,weakly positive expression in 3,negative expression in 8,respectively.Rank-sum test showed that the difference in MOGAT2 expression in the pterygium and normal conjunctiva tissues was statistically significant(Z =-2.403,P =0.016).There was no significant difference in the expression of MOGAT2 between the different age and the sex patients with pterygium (all P ＞ 0.05),and there was no significant correlation of MOGAT2 expression with education,occupation,income,protection in outdoor work,smoking,drinking,blood sugar,blood pressure,primary and recurrence pterygium,but significant correlation with the clinical stage of pterygium,that is,MOGAT2 expression in advanced pterygium was overexpressed when compared with tumor tissues in quiescent stage (P ＜ 0.05).Conclusion MOGAT2 is highly expressed in pterygium tissues,and the expression in advanced pterygium was significantly upregulated,of which is related to the formation and development of pterygium.关键词
翼状胬肉/MOGAT2/免疫组织化学Key words
pterygium/MOGAT2/immunohistochemistry分类
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秦柏,黄剑飞,张俊芳,朱惠君,杨梅,杨铃,钱晶晶,梁舒,吴玉宇,陆宏..单酰甘油酰基转移酶2(MOGAT2)在翼状胬肉组织中的表达及意义[J].眼科新进展,2018,38(2):156-160,5.
