中国当代儿科杂志2018，Vol.20Issue(3)：214-217,4.DOI:10.7499/j.issn.1008-8830.2018.03.010
TOPK/PBK在儿童恶性淋巴瘤与淋巴结反应性增生的淋巴结组织表达的研究
Expression of TOPK/PBK in children with malignant lymphoma or reactive lymphoid hyperplasia
摘要
Abstract
Objective To study the difference in expression of TOPK/PBK in lymph nodes between children with malignant lymphoma and those with reactive lymphoid hyperplasia. Methods Eighty children with malignant lymphoma and twenty children with reactive lymphoid hyperplasia were enrolled as subjects. Immunohistochemistry was used to determine the expression of TOPK/PBK in all the subjects. The expression of TOPK/PBK was compared between the two groups. Results The TOPK/PBK-positivity rate was significantly higher in children with malignant lymphoma than in those with reactive lymphoid hyperplasia (P<0.05). There was no significant difference in the TOPK/PBK-positivity rate between the children with Hodgkin's lymphoma and non-Hodgkin's lymphoma (NHL). There were significant differences in the TOPK/PBK-positivity rate among children with different pathological types of NHL (P<0.05): the children with lymphoblastic lymphoma showed the highest TOPK/PBK-positivity rate and those with mature B-cell lymphoma and mature T/NK-cell lymphoma had a similar TOPK/PBK-positivity rate. Conclusions The expression of TOPK/PBK is up-regulated in the lymph nodes of children with malignant lymphoma. The expression level of TOPK/PBK may be related to the pathological type of NHL.关键词
TOPK/PBK/恶性淋巴瘤/淋巴结反应性增生/儿童Key words
TOPK/PBK/Malignant lymphoma/Reactive lymphoid hyperplasia/Child引用本文复制引用
田鑫,贺湘玲,袁小叶,邹润英,邹惠,游亚兰,陈可可,朱呈光..TOPK/PBK在儿童恶性淋巴瘤与淋巴结反应性增生的淋巴结组织表达的研究[J].中国当代儿科杂志,2018,20(3):214-217,4.基金项目
长沙市科技计划项目长财企指[2017]53号(Kq1701055) （Kq1701055）
湖南省教育厅优秀青年项目(17B163). （17B163）
