中国耳鼻咽喉颅底外科杂志2018，Vol.24Issue(1)：62-65,4.DOI:10.11798/j.issn.1007-1520.201801014
变应性鼻炎大鼠鼻黏膜组织中血管细胞黏附因子-1与Eotaxin的表达及临床意义
Expressions and clinical significances of vascular cell adhesion molecule-1 and Eotaxin in rat nasal mucosa of allergic rhinitis
李颖 1李玉杰 1于敏 1黄炜1
作者信息
- 1. 郑州大学附属郑州中心医院耳鼻咽喉头颈外科,河南郑州450007
- 折叠
摘要
Abstract
Objective To study the expressions and clinical significances of vasular cell adhesion molecule-1 (VCAM-1) and Eotaxin in rat nasal mucosa of allergic rhinitis (AR).Methods 40 Healthy SD rats were randomly divided into two groups:AR group and control group.Model of AR was established in rats with ovalbumin sensitization.HE staining and toluidine blue staining (TBS) were used to observe the pathological changes of the nasal mucosa.The expressions of VCAM-1 and Eotaxin were detected by SP immunohistochemical assay.Results Pathological examination revealed obvious swelling of nasal mucosa with abundant inflammatory cell infiltration in AR group,and no abnormal changes in the control group.The expressions of VCAM-1 and Eotaxin in the AR group were significantly higher than those in the control group,and the differences were both statistically significant (both P ＜ 0.01).In the AR group,the expression of VCAM-1 was positively correlated with that of Eotaxin (r =0.886,P ＜ 0.01).Conclusion Eotaxin and VCAM-1 may participate in the pathogenesis of AR in synergy.关键词
变应性鼻炎/大鼠/血管细胞黏附因子-1/EotaxinKey words
Rhinitis, allergic/Rat/VCAM-1/Eotaxin分类
医药卫生引用本文复制引用
李颖,李玉杰,于敏,黄炜..变应性鼻炎大鼠鼻黏膜组织中血管细胞黏附因子-1与Eotaxin的表达及临床意义[J].中国耳鼻咽喉颅底外科杂志,2018,24(1):62-65,4.
