中国防痨杂志2017，Vol.39Issue(12)：1343-1347,5.DOI:10.3969/j.issn.1000-6621.2017.12.017
核苷酸结合寡聚化结构域样受体对结核分枝杆菌免疫应答研究的新进展
Recent research progress of the nucleotide-binding oligomerization domain-like receptor immune response to Mycobacterium tuberculosis infection
摘要
Abstract
Mycobacterium tuberculosis (MTB) is the main pathogenic bacteria of Tuberculosis (TB).The immune responses of the host play an important role in the process of tuberculosis pathogenesis,which mainly work dependent on pattern recognition receptors (PPRs).Nucleotide-binding oligomerization domain-like receptor (NLR) is one of the important PPRs,which plays a vital role in the infection and pathogenesis of MTB.More than 20 types of NLR have been discovered hitherto.NLR primarily responses to intracellular bacteria and viruses,as well as the products released or degraded from these microorganisms.NLR functions in the process of recognition and elimina tion of pathogens by innate immune system in the early infection of MTB,as well as initiating adaptive immune response,secreting cytokines and inducing inflammation and autophagy.In recent years,the study of NLR has got new progress.In this paper,the immune response to MTB infection mediated by NLR and its relationship with the TB pathogenesis were analyzed comprehensively,so as to provide new clues for the study of interaction between MTB and host cells.关键词
受体,模式识别/受体,蛋白酶激活/分枝杆菌,结核/感染/免疫Key words
Receptors, pattern recognition/Receptors, proteinase-activated/Mycobacterium tuberculosis/Infection/Immunity引用本文复制引用
张雨晴,张旭霞,刘毅,李传友..核苷酸结合寡聚化结构域样受体对结核分枝杆菌免疫应答研究的新进展[J].中国防痨杂志,2017,39(12):1343-1347,5.基金项目
首都卫生发展科研专项(首发2014-4-2163) （首发2014-4-2163）
北京市医院管理局青苗计划(QML20161601) （QML20161601）
