中国临床药理学与治疗学2017，Vol.22Issue(12)：1321-1325,5.
新疆维吾尔族粪样中具核梭杆菌水平与2型糖尿病的相关性研究
Relationship of Fusobacterium nucleatum levels in gut microbiota with type 2 diabetes mellitus in Uygurs of Xinjiang
摘要
Abstract
AIM:To detect the levels of Fusobacterium nucleatum in Uygurs of Xinjiang with normal glucose tolerance (NGT) or type 2 diabetes mellitus (T2DM) and to analyze the correlation between Fusobacterium nucleatum level and type 2 diabetes mellitus.METHODS:Blood and fecal samples were collected from Uygurs of Xinjiang with NGT or T2DM respectively.16SrDNA quantitative real-time PCR technology was used to detect the levels of Fusobacterium nucleatum in fecal samples.The correlations between Fusobacterium nucleatum and BMI,TC,TG,HDL and LDL levels were analyzed by Pearson.RESULTS:(1) The levels of Fusobacterium nucleatum in Uygurs T2DM group were significantly higher than those in Uygurs NGT group (P =0.011).(2) Fusobacterium nucleatum was positively correlated with the levels of BMI (r =0.335,P =0.049),TC(r =0.472,P =0.011)and LDL(r =0.368,P =0.029).CONCLUSION:The levels of Fusobacterium nucleatum may be closely related to lipid metabolism of T2DM in Uygurs.关键词
具核梭杆菌/2型糖尿病/实时荧光定量PCRKey words
Fusobacterium nucleatum/type 2 diabetes mellitus/quantitative real-time PCR分类
医药卫生引用本文复制引用
王蟾月,王烨,张培培,陈明月,杨浩,朱曼丽,李琳琳..新疆维吾尔族粪样中具核梭杆菌水平与2型糖尿病的相关性研究[J].中国临床药理学与治疗学,2017,22(12):1321-1325,5.基金项目
国家自然科学基金联合基金优青项目(U1403322) （U1403322）
