中国临床药理学与治疗学2017，Vol.22Issue(12)：1358-1363,6.
花参子露对小鼠慢性湿疹模型的疗效研究
Effects of Huashenzilu on chronic eczema in mice model
严丹丹 1黄芳 1徐丽华2
作者信息
- 1. 中国药科大学,南京211100,江苏
- 2. 苏州思源天然产物研发有限公司,苏州215000,江苏
- 折叠
摘要
Abstract
AIM:To observe clinical the effects of Huashenzilu on mice models with acute and chronic eczema.METHODS:Eczema was induced by repeated local exposure to DNCB,and then the mice received Huashenzilu.Using ELISA kit method to test the serum concentration of IL-2,IL-4,TNF-α,IFN-γ,and HE staining to test histopathological changes.The ear swelling and scratching index were measured,and ear allergy score were measured according to the standard for evaluation.RESULTS:After the treatment of Huashenzilu,the serum concentration of IL-4,TNF-α significantly increased and the serum concentration of IL-2,IFN-γ significantly decreased in the chronic mice compared to the model group (P ＜ 0.01).The ear swelling,scratching index and ear allergy score were significantly decreased.The phenomenon of epidermal thickening,acanthosis layer cavitation,and mast cells,macrophages infiltration were improved compared to the model group.CONCLUSION:Huashenzilu can control the chronic eczema in mice through the mechanism of regulating the balance between Th1 and Th2 immune response.关键词
花参子露/慢性湿疹/免疫反应Key words
Huashenzilu/chronic eczema/immune response分类
医药卫生引用本文复制引用
严丹丹,黄芳,徐丽华..花参子露对小鼠慢性湿疹模型的疗效研究[J].中国临床药理学与治疗学,2017,22(12):1358-1363,6.
