中国临床药理学与治疗学2017，Vol.22Issue(12)：1410-1414,5.
不同强度华法林在冠状动脉粥样硬化性心脏病并发心房颤动患者中的效果对比
Effects of different intensities of warfarin on patients with coronary atherosclerotic heart disease complicated with atrial fibrillation: a comparative study
摘要
Abstract
AIM:To explore the effects of different intensity of warfarin on patients with coronary atherosclerotic heart disease complicated with atrial fibrillation.METHODS:One hundred and seven cases of coronary heart disease complicated with atrial fibrillation patients in our hospital were selected and were randomly divided into experimental group (n =54) and control group (n =53) by random number table.The experimental group (low intensity) received initial amount of warfarin for 1.25 mg/d,and NR monitoring 24 h after treatment,if INR＜ 1.4,3-5 mg/d increased by 0.5-1.0 mg/d,monitoring one time per week,INR maintained within 1.4-2.0.INR of the control group (medium intensity) maintained within 2.0-2.6.One month monitoring after INR stabilized.All patients were treated for about 4 weeks,and warfarin was maintained at a dose of 1.25-7.5 mg/d.The primary and secondary end points and bleeding events were observed and compared after 2 years of treatment.RESULTS:The INR of the experimental group and the control group were 1.71 ± 0.38,2.36 ± 0.35,respectively.The ratio of total bleeding event of the experimental group and the control group was 22.2％ and 41.5％,respectively.Those of the experimental group were lower than those of the control group,and the difference was all statistically significant (P＜ 0.05).CONCLUSION:The efficacy of low-intensity warfarin in the treatment of coronary atherosclerotic heart disease complicated with atrial fibrillation is comparable to that of moderate-intensity warfarin therapy,but low-intensity warfarin shows better saftey.关键词
华法林/冠状动脉粥样硬化性心脏病/心房颤动/疗效Key words
warfarin/coronary heart disease/atrial fibrillation/curative effect分类
医药卫生引用本文复制引用
王世奇,胡烨文,陈晓敏,王健,叶红华..不同强度华法林在冠状动脉粥样硬化性心脏病并发心房颤动患者中的效果对比[J].中国临床药理学与治疗学,2017,22(12):1410-1414,5.基金项目
浙江省宁波市科技计划项目(2011C51003) （2011C51003）
