中国临床药理学与治疗学2018，Vol.23Issue(1)：24-28,5.DOI:10.12092/j.issn.1009-2501.2018.01.005
抗衰灵膏延缓衰老作用及其机制研究
Anti-aging effects of Kangshuailing ointment and its mechanism
摘要
Abstract
AIM:To observe the anti-aging effects of Kangshuailing ointment and the possible mechanisms.METHODS:ICR mice were randomly divided into six groups:normal group,model group,positive group,Kangshuailing ointment 1.3,2.6,5.2 g/kg group.Aging model was induced by subcutaneously injecting mice with 5 ％ D-galactose.Mice of each group receiced daily administration by gavage for 6 weeks.Thymus index and spleen index were calculated;LPO,LF contents and MAO-B activity in brain tissue were detected by ELISA method;MDA contents,SOD and GSH-Px activities in blood serum were examined by spectrophotometry method;the pathology change of brain tissues were observed using light microscope.RESULTS:Compared with model group,Kangshuailing ointment could significantly increase the thymus and spleen index,reduce the LPO and LF contents,and increase MAO-B activity in brain tissue,remarkably decrease the MDA contents and increase the SOD and GSH-Px activities in blood serum.In addition,Kangshuailing ointment could markedly relieve the pathological lesions induced with D-galactose in brain.CONCLUSION:Kangshuailing ointment has obvious anti-aging effect on aging mice,which may be related to the antioxidation.关键词
衰老/抗衰灵膏/抗氧化/D-半乳糖Key words
aging/Kangshuailing ointment/antioxidation/D-galactose分类
医药卫生引用本文复制引用
罗胜勇,邓学峰,刘澎,李成网,李睿..抗衰灵膏延缓衰老作用及其机制研究[J].中国临床药理学与治疗学,2018,23(1):24-28,5.基金项目
安徽省自然科学基金资助项目(1608085MH161) （1608085MH161）
