中国临床药理学与治疗学2018，Vol.23Issue(1)：47-50,4.DOI:10.12092/j.issn.1009-2501.2018.01.009
阿那其根醇提取物对两种炎症模型作用机制研究
Mechanism of ethanolic extract of root of Anacyclus pyrethrum on two models of inflammation
摘要
Abstract
AIM:To study the effects of ethanolic extract of root of Anacyclus pyrethrum (EERAP) on two models of inflammation.METHODS:Fifty mice were randomly divided into Control group (received water),EERAP groups of high dose (640mg/kg),middle dose (320 mg/kg),low dose (160 mg/kg) and Aspirin (120 mg/kg) group.Two models of inflammation were established through mice induced by xylene and RAW264.7 cells induced by lipopolysaccharide (LPS).The anti-inflammatory and antioxidant activity mechanisms were investigated by detecting the contents of malondialdehyde (MDA) in inflammatory tissue,the activity of SOD in serum,while NF-κB and TNF-α in RAW264.7 cells.RESULTS:Compared with the control group,different concentrations of EERAP had significant inhibition on the auricle swelling and capillary permeability (P ＜ 0.01),and increased the activity of SOD and MDA in serum in mice in vivo (P ＜ 0.01),while reduced the contents of TNF-α and NF-κB in RAW264.7 cells in vitro.CONCLUSION:The anti-inflammatory and antioxidant activity mechanism of EERAP might be related to the reduction of MDA and NF-κB,and the elevation of SOD and NF-κB.关键词
阿那其根醇提取物/炎症模型/抗炎/抗氧化Key words
Anacyclus pyrethrum/inflammatory model/anti-inflammatory/antioxidant分类
医药卫生引用本文复制引用
黄海,刘长江,金小越..阿那其根醇提取物对两种炎症模型作用机制研究[J].中国临床药理学与治疗学,2018,23(1):47-50,4.基金项目
新疆维吾尔自治区自然科学基金(2013211A056) （2013211A056）
