中国临床药理学与治疗学2018，Vol.23Issue(1)：55-58,4.DOI:10.12092/j.issn.1009-2501.2018.01.011
尼索地平对离体人子宫动脉收缩的影响
Antagonistic effects of nisoldipine on the contractile response of human uterine artery
摘要
Abstract
AIM:To study the effects of nisoldipine on the contractile response of isolated human uterine artery induced by potassium chloride (KCl) and phenylephrine (PHE).METHODS:Isolated artery experiment was conducted to observe the antagonistic effects of nisoldipine on the contraction induced by KCl and PHE in isolated human uterine arterial rings in the calciferous and calcium-free K-H solution.RESULTS:In the calciferous K-H solution,the contractile response ofisolated human uterine artery induced by KCl (50 mmol/L,80 mmol/L) and PHE[(1 ×10-6)mol/L,(5 ×10-6)mol/L)] were inhibited by nisoldipine.The IC50 were [(7.52 ± 1.33) × 10-9 mol/L,(2.75 ±0.53) ×10-7mol/L] and [(6.17±1.21) ×10-8 mol/L,(1.51 ±0.49) × 10-6 mol/L],respectively.In the calcium-free K-H solution,nisoldipine showed no effect.CONCLUSION:The contractile response of isolated human uterine artery can be inhibited by nisoldipine.关键词
尼索地平/硝苯地平/人子宫动脉/氯化钾/去氧肾上腺素Key words
nisoldipine/nifedipine/human uterine artery/KCl/PHE分类
医药卫生引用本文复制引用
杜梅素,杨波,刘雪芹,魏国会,张新霞,韩宗其,郭民英..尼索地平对离体人子宫动脉收缩的影响[J].中国临床药理学与治疗学,2018,23(1):55-58,4.基金项目
邢台市科技计划基金项目(2015zz027-4) （2015zz027-4）
