中国临床药理学杂志2017，Vol.33Issue(23)：2335-2338,4.DOI:10.13699/j.cnki.1001-6821.2017.23.003
替格瑞洛片治疗复杂冠心病的临床研究
Clinical trial of ticagrelor tablets in the treatment of complex coronary artery disease
摘要
Abstract
Objective To observe the clinical efficacy and safety of ticagrelor tablets in the treatment of complex coronary artery disease.Methods One hundred and twenty-five patients with complex coronary artery disease were randomly divided into control group (n =63 cases) and treatment groups (n =62 cases).Control group received clopidogrel hydrogen 300 mg per time before operation and 75 mg per time after operation,qd,orally.Treatment group was given ticagrelor 180 mg per time before operative and 90 mg per time after operation,qd,orally.Two groups were treated for 1 year.The clinical efficacy,cardiac function and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 87.10％ (54 cases/62 cases) and 71.43％ (45 cases/63 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:creatinine kinase-MB were (16.37 ±2.01) and (59.73 ± 10.62) μg · L-1,myoglobin were (42.08 ± 11.86) and (123.28 ± 50.63) μg · L-1,troponin T were (0.01 ±0.01) and (0.06 ± 0.03) μg · L-1,brain natriuretic peptide were (44.44 ± 3.11) and (68.62 ± 10.37) ng · L-1,left ventricular ejection fraction were (57.22 ± 1.61) ％ and (25.36±5.38)％,the differences were statistically significant (all P ＜0.05).The adverse drug reactions in two groups were bleeding,difficulty breathing and arrhythmia.The incidences of adverse drug reactions in treatment and control groups were 24.19％ and 31.75％ without significant difference (P ＞ 0.05).Conclusion Ticagrelor tablets have a definitive clinical efficacy in the treatment of complex coronary artery disease,which can significantly improve the cardiac functions,without increasing the incidence of adverse drug reactions.关键词
替格瑞洛片/复杂冠心病/安全性Key words
ticagrelor tablet/complex coronary artery disease/safety分类
医药卫生引用本文复制引用
周帅,赵洛沙,黄克钧..替格瑞洛片治疗复杂冠心病的临床研究[J].中国临床药理学杂志,2017,33(23):2335-2338,4.基金项目
河南省科技攻关基金资助项目(201403235) （201403235）
